Opportunities and challenges of physiologically based pharmacokinetic modeling in drug delivery
W Wang, D Ouyang - Drug Discovery Today, 2022 - Elsevier
Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …
and development.•The PBPK is often used in oral formulation development, to address …
An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation …
Drugs in solid dispersion (SD) take advantage of fast and extended dissolution, thus attains
a higher bioavailability than the crystal form. However, current development of SD relies on …
a higher bioavailability than the crystal form. However, current development of SD relies on …
In silico modeling and simulation to guide bioequivalence testing for oral drugs in a virtual population
F Zhang, R Jia, H Gao, X Wu, B Liu, H Wang - Clinical Pharmacokinetics, 2021 - Springer
Abstract Model-informed drug discovery and development (MID3) shows great advantages
in facilitating drug development. A physiologically based pharmacokinetic model is one of …
in facilitating drug development. A physiologically based pharmacokinetic model is one of …
[HTML][HTML] Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability
Z Wang, M Sun, T Liu, Z Gao, Q Ye, X Tan… - Asian Journal of …, 2019 - Elsevier
Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve
the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize …
the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize …
Accelerated repurposing and drug development of pulmonary hypertension therapies for COVID-19 treatment using an AI-integrated biosimulation platform
The COVID-19 pandemic has reached over 100 million worldwide. Due to the multi-targeted
nature of the virus, it is clear that drugs providing anti-COVID-19 effects need to be …
nature of the virus, it is clear that drugs providing anti-COVID-19 effects need to be …
Evaluating the bioequivalence of two pitavastatin calcium formulations based on IVIVC modeling and clinical study
J Wang, J Chen, L Wang, D Yang… - Clinical and …, 2023 - Wiley Online Library
In vitro‐in vivo correlation (IVIVC) allows prediction of the in vivo performance of a
pharmaceutical product based on its in vitro drug release profiles and can be used to reduce …
pharmaceutical product based on its in vitro drug release profiles and can be used to reduce …
Evaluating the bioequivalence of metronidazole tablets and analyzing the effect of in vitro dissolution on in vivo absorption based on PBPK modeling
S Zhang, M Fang, Q Zhang, X Li… - Drug Development and …, 2019 - Taylor & Francis
Metronidazole, a BCS class I drug, could be waived based on the BCS principles, thus
enabling in vitro dissolution data as a surrogate of BE study. However, the impact of …
enabling in vitro dissolution data as a surrogate of BE study. However, the impact of …
Analytical Methods of Dihydropyridines Based Calcium Channel Blockers-Amlodipine, Lacidipine, Isradipine, Nifedipine, Felodipine, Cilnidipine and its related …
PK Chatki, S Tabassum - 2021 - indianjournals.com
Objectives: Various analytical techniques are applied in pharmaceutical field to estimate the
quality of active pharmaceutical ingredients, amount of drug in biological fluids and in …
quality of active pharmaceutical ingredients, amount of drug in biological fluids and in …
Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid …
MM Alsmadi, NM Al-Daoud, RM Obaidat… - AAPS …, 2022 - Springer
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are common disorders
that can change the body's physiology and drugs pharmacokinetics. Solid dispersion (SD) …
that can change the body's physiology and drugs pharmacokinetics. Solid dispersion (SD) …
In vivo screening of oral formulations using rats: Effects of ingested water volume on oral absorption of BCS class I and III drugs from immediate-release formulations
M Kataoka, S Morimoto, K Minami, H Higashino… - Journal of Drug Delivery …, 2020 - Elsevier
This study investigated the effects of ingested water volume on drug absorption to confirm
the applicability of rats for oral formulation screening and to optimize the experimental …
the applicability of rats for oral formulation screening and to optimize the experimental …