The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Liver cancer is one of the most common malignancies, with severe morbidity and mortality.
While considerable progress has been made in liver cancer treatment, the 5-year overall …

The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …

Simple Summary A rapidly emerging new approach to treat cancer involves collection of
patient immune white blood cells and genetic re-programming of the cells to express a new …

Different sources of mutagenesis cause consistently identifiable patterns of mutations and
mutational signatures that mirror the various carcinogenetic processes. We used publicly …

Circulating tumor DNA (ctDNA) carries tumor-specific genetic and epigenetic variations. To
identify extranodal natural killer/T cell lymphoma (ENKTL)-specific methylation markers and …

Background: The arterial pole of the heart is a hotspot for life-threatening forms of congenital
heart defects (CHDs). Development of this cardiac region occurs by addition of Second …

Background The exact mechanisms of type 2 diabetes mellitus (T2DM) remain largely
unknown. We intended to authenticate critical genes linked to T2DM progression by tandem …

Delta like non-canonical Notch ligand 1 (DLK1), as a member of epidermal growth factor-like
family, plays a critical role in somatic growth, tissue development and possibly tissue …

Background Delta‐like homologue 1 (DLK1), a transmembrane protein, is highly expressed
in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen …