E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers
HB Park, KH Baek - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …
module of various cellular processes such as cell proliferation, differentiation, and stress …
[HTML][HTML] Biomarker discovery and application—an opportunity to resolve the challenge of liver cancer diagnosis and treatment
J Chen, C Niu, N Yang, C Liu, S Zou, S Zhu - Pharmacological Research, 2023 - Elsevier
Liver cancer is one of the most common malignancies, with severe morbidity and mortality.
While considerable progress has been made in liver cancer treatment, the 5-year overall …
While considerable progress has been made in liver cancer treatment, the 5-year overall …
Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty
MF Faienza, F Urbano, LA Moscogiuri… - Frontiers in …, 2022 - frontiersin.org
The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …
CAR-based immunotherapy of solid tumours—a survey of the emerging targets
J Maher, DM Davies - Cancers, 2023 - mdpi.com
Simple Summary A rapidly emerging new approach to treat cancer involves collection of
patient immune white blood cells and genetic re-programming of the cells to express a new …
patient immune white blood cells and genetic re-programming of the cells to express a new …
[HTML][HTML] Mutational signatures and their association with survival and gene expression in urological carcinomas
P Karihtala, O Kilpivaara, K Porvari - Neoplasia, 2023 - Elsevier
Different sources of mutagenesis cause consistently identifiable patterns of mutations and
mutational signatures that mirror the various carcinogenetic processes. We used publicly …
mutational signatures that mirror the various carcinogenetic processes. We used publicly …
Diagnostic performance and prognostic value of circulating tumor DNA methylation marker in extranodal natural killer/T cell lymphoma
XP Tian, YC Zhang, NJ Lin, L Wang, ZH Li, HG Guo… - Cell Reports …, 2023 - cell.com
Circulating tumor DNA (ctDNA) carries tumor-specific genetic and epigenetic variations. To
identify extranodal natural killer/T cell lymphoma (ENKTL)-specific methylation markers and …
identify extranodal natural killer/T cell lymphoma (ENKTL)-specific methylation markers and …
PPARγ and NOTCH Regulate Regional Identity in the Murine Cardiac Outflow Tract
M Rammah, M Théveniau-Ruissy, R Sturny… - Circulation …, 2022 - Am Heart Assoc
Background: The arterial pole of the heart is a hotspot for life-threatening forms of congenital
heart defects (CHDs). Development of this cardiac region occurs by addition of Second …
heart defects (CHDs). Development of this cardiac region occurs by addition of Second …
Identification and validation of core genes for type 2 diabetes mellitus by integrated analysis of single-cell and bulk RNA-sequencing
T Yang, C Yan, L Yang, J Tan, S Jiang, J Hu… - European Journal of …, 2023 - Springer
Background The exact mechanisms of type 2 diabetes mellitus (T2DM) remain largely
unknown. We intended to authenticate critical genes linked to T2DM progression by tandem …
unknown. We intended to authenticate critical genes linked to T2DM progression by tandem …
DLK1 promoted ischemic angiogenesis through notch1 signaling in endothelial progenitor cells
Y You, N Zhang, Z Wang, Z Yin, Q Bao, S Lei… - Acta Pharmacologica …, 2024 - nature.com
Delta like non-canonical Notch ligand 1 (DLK1), as a member of epidermal growth factor-like
family, plays a critical role in somatic growth, tissue development and possibly tissue …
family, plays a critical role in somatic growth, tissue development and possibly tissue …
DLK1‐directed chimeric antigen receptor T‐cell therapy for hepatocellular carcinoma
Y Zhai, K He, L Huang, X Shang, G Wang… - Liver …, 2022 - Wiley Online Library
Background Delta‐like homologue 1 (DLK1), a transmembrane protein, is highly expressed
in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen …
in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen …