This review article offers a detailed examination of metabolic adaptations in pressure
overload hypertrophic hearts, a condition that plays a pivotal role in the progression of heart …

Background Therapies are urgently required to ameliorate pathological cardiac hypertrophy
and enhance cardiac function in heart failure. Our preliminary experiments have …

Since its initial discovery in 1994, the adipokine leptin has received extensive interest as an
important satiety factor and regulator of energy expenditure. Although produced primarily by …

Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-
lowering and weight loss medication due to its effects on energy metabolism. In heart failure …

Macrophage-orchestrated inflammation contributes to multiple diseases including sepsis.
However, the underlying mechanisms remain to be defined clearly. Here, we show that …

Metabolic reprogramming is critical in the onset of pressure overload–induced cardiac
remodeling. Our study reveals that proline dehydrogenase (PRODH), the key enzyme in …

Exposure to PM 2.5 is correlated with cardiac remodeling, of which cardiac hypertrophy is
one of the main clinical manifestations. Ferroptosis plays an important role in cardiac …

Cardiomyopathy is a common complication and significantly increases the risk of death in
septic patients. Our previous study demonstrated that post-treatment with dexmedetomidine …

Cardiomyocyte maturation during pre-and postnatal development requires multiple
intertwined processes, including a switch in energy generation from glucose utilization in the …

Background The effects of diabetes on the cardiac and aortic structure and function remain
unclear. Detecting and intervening these variations early is crucial for the prevention and …