Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure
with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction …

Diabetes mellitus is currently a major public health problem. A common complication of
diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads …

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

Background Sodium glucose co-transporter 2 inhibitor (SGLT2i), a new class of anti-diabetic
drugs acting on inhibiting glucose resorption by kidneys, is shown beneficial in reduction of …

In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that
parallels the increased prevalence of obesity and which markedly increases the risk of …

Since diabetic cardiomyopathy was first reported four decades ago, substantial information
on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances …

Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

The presence of a diabetic cardiomyopathy, independent of hypertension and coronary
artery disease, is still controversial. This systematic review seeks to evaluate the evidence …