Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical
implications for patients and significant economic consequences for society. The prevalence …

The concept of a minimal clinically important difference (MCID) is well established. Here, we
review the evidence base and methods used to define MCIDs as well as their strengths and …

Exacerbations of chronic obstructive pulmonary disease (COPD) determine disease-
associated morbidity, mortality, resource burden and healthcare costs. Acute exacerbation …

Clinical trials evaluating the management of acute exacerbations of COPD assess
heterogeneous outcomes, often omitting those that are clinically relevant or more important …

Background Exacerbations affect morbidity in chronic obstructive pulmonary disease
(COPD). We sought to evaluate the association between exacerbation frequency and …

Background Rates of mortality and readmission are high in patients hospitalised with acute
exacerbations of chronic obstructive pulmonary disease (AECOPD). In this population, the …

Background COPD exacerbations are associated with accelerated lung function decline, but
whether they are causal is unknown. We evaluated the effect of a single exacerbation on …

Chronic obstructive pulmonary disease patient care must include confirming a diagnosis
with postbronchodilator spirometry. Because of the clinical heterogeneity and the reality that …

Rationale: Although exacerbations are an important problem in chronic obstructive
pulmonary disease (COPD) and a target of intervention, there is no valid, standardized tool …

Background Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition predisposing
individuals to chronic obstructive pulmonary disease (COPD). The treatment is generally …