Post‑ischemic neuroinflammation induced by the innate local immune response is a major
pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of …

Alzheimer's disease (AD; progressive neurodegenerative disorder) is associated with
cognitive and functional impairment with accompanying neuropsychiatric symptoms. The …

Parkinson's disease (PD) is a neurodegenerative disease (NDD) with high and ongoing
morbidity, bringing heavy burdens to PD patients seriously. Finding neurotrophic drugs still …

Based on the etiology, stroke can be classified into ischemic or hemorrhagic subtypes,
which ranks second among the leading causes of death. Stroke is caused not only by …

Ischemic-induced white matter injury is strongly correlated with the poor neurological
outcomes in stroke patients. The transplantation of oligodendrocyte precursor cells (OPCs) …

NANOG plays a key role in cellular plasticity and the acquisition of the stem cell state during
reprogramming, but its role in the regenerative process remains unclear. Here, we show that …

The protein kinase R-like endoplasmic reticulum kinase/eukaryotic initiation factor 2ɑ
(PERK/eIF2α), the branch of unfolded protein response (UPR), is responsible for transient …

Grip strength is a valuable preclinical assay to study muscle physiology in disease and
aging by directly determining changes in muscle force generation in active laboratory mice …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system characterized by remyelination failure, axonal degeneration, and progressive …

Stroke remains one of the most important causes of death and disability. Preclinical research
is a powerful tool for understanding the molecular and cellular response to stroke. However …