Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin
filaments in fungi and metazoans. Tpms are coiled-coil parallel dimers that form a head-to …

We argue that the overall behavior of tropomyosin on F-actin cannot be easily discerned by
examining thin filaments reduced to their smallest interacting units. In isolation, the …

Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments
and a modulator of cardiac muscle contraction. Defects in the cardiac isoform, cMyBP-C …

Wrapped superhelically around actin filaments, the coiled-coil α-helices of tropomyosin
regulate muscle contraction by cooperatively blocking or exposing myosin-binding sites on …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease
characterized by left ventricular hypertrophy, diastolic dysfunction, and myocardial disarray …

Life-threatening ventricular arrhythmias are the main clinical burden in patients with
hypertrophic cardiomyopathy (HCM), and frequently occur in young patients with mild …

Aims Citrullination, the post-translational conversion of arginine to citrulline by the enzyme
family of peptidylarginine deiminases (PADs), is associated with several diseases, and …

The interactions of cytoskeletal actin filaments with myosin family motors are essential for the
integrity and function of eukaryotic cells. They support a wide range of force-dependent …

The actin cytoskeleton is regulated by a variety of actin-binding proteins including those
constituting the tropomyosin family. Tropomyosins are coiled-coil dimers that bind along the …