A review of pragmatic trials found a high degree of diversity in design and scope, deficiencies in reporting and trial registry data, and poor indexing
Objective We established a large database of trials to serve as a resource for future
methodological and ethical analyses. Here, we use meta-data to describe the broad …
methodological and ethical analyses. Here, we use meta-data to describe the broad …
[HTML][HTML] Analysis of the characteristics and the degree of pragmatism exhibited by pragmatic-labelled trials of antineoplastic treatments
R Saesen, K Depreytere, K Krupianskaya… - BMC Medical Research …, 2023 - Springer
Abstract Background Pragmatic clinical trials (PCTs) are designed to reflect how an
investigational treatment would be applied in clinical practice. As such, unlike their …
investigational treatment would be applied in clinical practice. As such, unlike their …
The design can limit PRECIS-2 retrospective assessment of the clinical trial explanatory/pragmatic features
R Dal-Ré, A de Boer, SK James - Journal of Clinical Epidemiology, 2020 - jclinepi.com
The pragmatic-explanatory continuum indicator summary (PRECIS-2) tool was originally
developed to help investigators to design their trials based on the intended purposes [1]. If …
developed to help investigators to design their trials based on the intended purposes [1]. If …
The importance of decision intent within descriptions of pragmatic trials
Objective It is now more than 50 years since the concepts of explanatory and pragmatic
attitudes toward trials were first discussed by Schwartz and Lellouch in their influential 1967 …
attitudes toward trials were first discussed by Schwartz and Lellouch in their influential 1967 …
The PRECIS-2 tool seems not to be useful to discriminate the degree of pragmatism of medicine masked trials from that of open-label trials
R Dal-Ré - European Journal of Clinical Pharmacology, 2021 - Springer
Purpose To assess, with all available trial information, whether the assessment of the
PRECIS-2 nine domains could provide a clear distinction between medicine masked …
PRECIS-2 nine domains could provide a clear distinction between medicine masked …
[HTML][HTML] Using PRECIS-2 in Chinese herbal medicine randomized controlled trials for irritable bowel syndrome: A methodological exploration based on literature
M Luo, Y Wang, J Huang, Y Li, W Li, H Li, Z Liu… - Integrative Medicine …, 2024 - Elsevier
Background The pragmatism levels of randomized controlled trials (RCTs) mean how similar
the interventions delivered in the trial setting match those in the setting where the results will …
the interventions delivered in the trial setting match those in the setting where the results will …
Articles provided insufficient information to conduct an appropriate retrospective assessment of the pragmatic/explanatory features of medicine trials with the PRECIS …
R Dal-Ré - European Journal of Clinical Pharmacology, 2020 - Springer
Purpose To assess whether, in the retrospective assessment of the pragmatic/explanatory
features of pragmatic randomized controlled trials (pRCTs), the nine PRECIS-2 domain …
features of pragmatic randomized controlled trials (pRCTs), the nine PRECIS-2 domain …
Generalizability of randomized controlled trials in primary health care: Applying the PRECIS‐2 tool on published protocols
E Papagiannopoulou, E Laiou, C Tatsi… - Journal of Evaluation …, 2023 - Wiley Online Library
Rationale Pragmatic design may facilitate the generalizability of effectiveness of randomized
controlled trials (RCTs) in primary health care (PHC). Aims and Objectives The aim of this …
controlled trials (RCTs) in primary health care (PHC). Aims and Objectives The aim of this …
Pragmatic trials, blinding, placebos, and the usefulness of the PRECIS-2 tool
R Dal-Ré - European Journal of Clinical Pharmacology, 2021 - Springer
Zwarenstein and Howie and I have fundamental different approaches and understanding on
the usefulness of the PRECIS-2 tool when retrospectively assessing the degree of …
the usefulness of the PRECIS-2 tool when retrospectively assessing the degree of …
[HTML][HTML] Perspectivas educativas e investigativas del pragmatismo en sociedades democráticas
JS Diago Camacho, P Páramo - Praxis & Saber, 2023 - scielo.org.co
El artículo presenta los resultados de una revisión sistemática de textos académicos
publicados entre 2012 y 2021, que integran los conceptos investigación, educación y …
publicados entre 2012 y 2021, que integran los conceptos investigación, educación y …