Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Glioblastoma vaccines: past, present, and opportunities

Z Xiong, I Raphael, M Olin, H Okada, X Li… - …, 2024 - thelancet.com
Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in
adults. As supplements to standard of care (SOC), various immunotherapies improve the …

Targeting the dendritic cell-T cell axis to develop effective immunotherapies for glioblastoma

B Gardam, T Gargett, MP Brown, LM Ebert - Frontiers in Immunology, 2023 - frontiersin.org
Glioblastoma is an aggressive primary brain tumor that has seen few advances in treatments
for over 20 years. In response to this desperate clinical need, multiple immunotherapy …

Application of three-dimensional (3D) bioprinting in anti-cancer therapy

BX Wu, Z Wu, YY Hou, ZX Fang, Y Deng, HT Wu, J Liu - Heliyon, 2023 - cell.com
Abstract Three-dimensional (3D) bioprinting is a novel technology that enables the creation
of 3D structures with bioinks, the biomaterials containing living cells. 3D bioprinted …

Bradykinin B1 Receptor Affects Tumor-Associated Macrophage Activity and Glioblastoma Progression

CK Shen, BR Huang, V Charoensaensuk, LY Yang… - Antioxidants, 2023 - mdpi.com
Bradykinin is a small active peptide and is considered an inflammatory mediator in several
pathological conditions. Bradykinin exerts its effects by coupling to its receptors, including …

Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer

E Memari, D Khan, R Alkins, B Helfield - Journal of Controlled Release, 2024 - Elsevier
Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can
transiently increase the permeability of the blood-brain barrier (BBB) to enable targeted …

H3G34-mutant gliomas—a review of molecular pathogenesis and therapeutic options

AV Nguyen, JM Soto, SM Gonzalez, J Murillo… - Biomedicines, 2023 - mdpi.com
The 2021 World Health Organization Classification of Tumors of the Central Nervous System
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …

Glioblastoma and brain connectivity: the need for a paradigm shift

A Salvalaggio, L Pini, A Bertoldo… - The Lancet Neurology, 2024 - thelancet.com
Despite substantial advances in cancer treatment, for patients with glioblastoma prognosis
remains bleak. The emerging field of cancer neuroscience reveals intricate functional …

Protein Disulfide Isomerase A3 (PDIA3): A Pharmacological Target in Glioblastoma?

G Paglia, M Minacori, G Meschiari, S Fiorini… - International Journal of …, 2023 - mdpi.com
The protein disulfide isomerase A3 (PDIA3) is directly or indirectly involved in various
physiopathological processes and participates in cancer initiation, progression and …

The glioblastoma circularRNAome

A Tirpe, C Streianu, SM Tirpe, A Kocijancic… - International Journal of …, 2023 - mdpi.com
Glioblastoma remains one of the most aggressive cancers of the brain, warranting new
methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) …