Etiological relationship between lipid metabolism and endometrial carcinoma

W Li, Y Xu, X Zeng, J Tan, Y Wang, H Wu, M Li… - Lipids in Health and …, 2023 - Springer
Endometrial carcinoma (EC) has become one of the most common gynecological malignant
neoplasms in developed countries worldwide. Studies have shown that this may be closely …

Statins and the risk of gastric cancer: a systematic review and meta-analysis

CH Su, MM Islam, G Jia, CC Wu - Journal of Clinical Medicine, 2022 - mdpi.com
Previous epidemiological studies have reported that the use of statins is associated with a
decreased risk of gastric cancer, although the beneficial effects of statins on the reduction of …

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

YZ Wu, KX Wang, X Ma, CC Wang… - … of Biochemical and …, 2023 - Wiley Online Library
Doxorubicin (DOX), is a high efficiency anthracycline antitumor drug. However, the clinical
application of DOX is limited mainly by dose‐related adverse drug reactions. Currently, the …

Altered cancer metabolism and implications for next-generation CAR T-cell therapies

R Ramapriyan, VS Vykunta, G Vandecandelaere… - Pharmacology & …, 2024 - Elsevier
This review critically examines the evolving landscape of chimeric antigen receptor (CAR) T-
cell therapy in treating solid tumors, with a particular focus on the metabolic challenges …

Estimation of energy pathway fluxes in cancer cells-Beyond the Warburg effect

R Moreno-Sánchez, DX Robledo-Cadena… - Archives of Biochemistry …, 2023 - Elsevier
Glycolytic and respiratory fluxes were analyzed in cancer and non-cancer cells. The steady-
state fluxes in energy metabolism were used to estimate the contributions of aerobic …

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer

Y Zheng, Z Zhou, G Wang, J Tu, H Cheng, S Ma… - Cell Death & …, 2023 - nature.com
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low.
MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with …

Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo

M Pereira, A Glogova, J Haagsma, J Stewart… - Journal of Ovarian …, 2023 - Springer
High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of
epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the …

An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma

A Holm, MS Graus, J Wylie-Sears, L Borgelt… - bioRxiv, 2024 - biorxiv.org
Infantile hemangioma (IH) is the most common tumor in children and a paradigm for
pathological vasculogenesis, angiogenesis and regression. Propranolol is the mainstay of …

[PDF][PDF] PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR …

SF De Silva - 2023 - harvest.usask.ca
Prostate cancer (PC) is the most commonly found malignancy among men globally. Many
genetic and epigenetic factors involving multiple cellular signaling networks are implicated …

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer

X Wu, YK Zheng, Z Zhou, J Tu, G Wang, H Cheng… - 2022 - researchsquare.com
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is extremely low.
microRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with …