BACKGROUND: Guidelines for prevention of group B streptococcal (GBS) infection have
successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia …

BACKGROUND: A sequential approach to young febrile infants on the basis of clinical and
laboratory parameters, including procalcitonin, was recently described as an accurate tool in …

Despite substantial progress in prevention of perinatal group B streptococcal (GBS) disease
since the 1990s, GBS remains the leading cause of early-onset neonatal sepsis in the …

Background The rate of bacterial meningitis declined by 55% in the United States in the
early 1990s, when the Haemophilus influenzae type b (Hib) conjugate vaccine for infants …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Background Despite widespread use of intrapartum antibiotic prophylaxis, group B
streptococcus remains a leading cause of morbidity and mortality in infants in Europe, the …

The epidemiology of bacterial meningitis has changed as a result of the widespread use of
conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the …

Streptococcus agalactiae (group B streptococcus (GBS)), remains the leading cause of
neonatal sepsis and meningitis in many countries and an important cause of disease in …

OBJECTIVE: To develop a quantitative model to estimate the probability of neonatal early-
onset bacterial infection on the basis of maternal intrapartum risk factors. METHODS: This …

Bacterial meningitis is a devastating infection, with a case fatality rate of up to 30% and 50%
of survivors developing neurological complications. These include short-term complications …