Both quality improvement and clinical research efforts over the past few decades have
focused on consensus definition of sepsis and acute respiratory distress syndrome (ARDS) …

The ability of the lung to perform gas exchange is made possible in part by the effective
relationship between the alveolar epithelium and the endothelium of the pulmonary …

Background Precision medicine approaches that target patients on the basis of disease
subtype have transformed treatment approaches to cancer, asthma, and other …

Purpose Using latent class analysis (LCA), we have consistently identified two distinct
subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has …

Background Subphenotypes have been identified within heterogeneous diseases such as
asthma and breast cancer, with important therapeutic implications. We assessed whether …

Importance Obesity, diabetes, and hypertension are common comorbidities in patients with
severe COVID-19, yet little is known about the risk of acute respiratory distress syndrome …

Background Bone marrow mesenchymal stem cell (BM-MSC)-derived extracellular vesicles
(ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs …

Background Acute lung injury (ALI) is a serious postoperative complication with limited
treatment options. A preoperative risk-prediction model would assist clinicians and scientists …

Background There is a compelling unmet medical need for biomarker-based models to risk-
stratify patients with acute respiratory distress syndrome. Effective stratification would …

Background The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS,
Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis …