Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …

Organic anion transporters 1 and 3 (OAT1 and OAT3) play a crucial role in kidney function
by regulating the secretion of multiple renally cleared small molecules and toxic metabolic …

Abstract Background The Metabolic reprogramming of tumor cells plays a vital role in the
progression of hepatocellular carcinoma. Organic cation/carnitine transporter 2 (OCTN2), a …

High uric acid is associated with gout, hypertension, metabolic syndrome, cardiovascular
disease, and kidney disease. URAT1 (SLC22A12), originally discovered in mice as Rst, is …

Per-and polyfluoroalkyl (PFAS) substances are a type of chemical compound unique for
their multiple carbon-fluorine bonds, imbuing them with strength and environmental …

Organic anion transporting polypeptide 1B1 (OATP1B1) is an influx transporter protein of the
SLC superfamily, expressed mainly in the liver and some tumor cells. The mechanisms of its …

We introduce a Bayesian approach for biclustering that accounts for the prior functional
dependence between genes using hidden Markov models (HMMs). We utilize biological …

Objectives: The current study aimed to correlate OCT1 (organic cation transporter 1)
polymorphisms with metformin response variability in Iraqi women with PCOS (polycystic …

Trace amines (TA), typified by p-tyramine (TYR) and 2-phenylethylamine (2-PE), function by
activating trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor. TAAR1 …

The organic cation transporters (OCT) 1, 2, and 3, along with the novel organic cation
transporters (OCTN) 1 and 2, are members of the Solute Carrier 22 (SLC22) family, these …