The concept of gliodegenerative diseases has not been widely established although there is
accumulating evidence that glial cells may represent a primary target of degenerative …

The main unifying feature of cases with frontotemporal dementia (FTD) is the pattern of brain
atrophy. Surprisingly, there are a variety of underlying histopathologies in cases with the …

Background: Clinical misdiagnosis, particularly at early disease stages, is a roadblock to
finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide …

Alzheimer's disease (AD) is characterized histopathologically by β-amyloid-containing
plaques, neurofibrillary tangles (NFT), reduced synaptic density, and neuronal loss in …

We have characterized a novel monoclonal antibody, Tau‐66, raised against recombinant
human tau. Immunohistochemistry using Tau‐66 reveals a somatic‐neuronal stain in the …

Glial cells have long been considered to play roles in the nervous system that are unexciting
compared with those of neurons. They provide neurons with nutrients, guide migrating …

Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid.
Currently, there is no clear understanding of the mechanisms underlying the contribution of …

A hypothesis is proposed to explain the pathogenesis of neurodegenerative disease and the
diversity of its phenotypes. The hypothesis is based on seven main propositions: 1) …

Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family. It is localized
within the cytoplasm and has unique substrate specificities for nonhistone proteins, such as …

Genetic evidence indicates that several mutations in tau, including G272V, are linked to
frontotemporal dementia with parkinsonism. We expressed this mutation in mouse brains by …