The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Guanine‐rich nucleic acid sequences able to form four‐stranded structures (G‐
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

The present paper reviews the recent advances in and applications of experimental
techniques used to study interactions between G-quadruplex structures and ligands that are …

Background: Guanosine (G)-rich DNA and RNA sequences can adopt a defined secondary
structure, the G-quadruplex, which consists of multiple stacked G-tetrads. Each G-tetrad has …

This G-rich region of the c-MYC promoter has been shown to form a G-quadruplex structure
that acts as a silencer element for c-MYC transcriptional control. In the present work, we …

Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …

A series of novel curcumin analogues were designed, synthesized, and evaluated as
potential multifunctional agents for the treatment of AD. The in vitro studies showed that …