PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

Abstract Aloe vera (Aloe barbadensis Miller) is a perennial succulent medicinal plant. It has
been used as a traditional or folk medicine for thousands of years and claimed that it …

The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …

Abstract Di-(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) are representative
phthalic acid esters (PAEs), a class of environmental endocrine disruptors used as …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized
by its sudden manifestation, rapid progression, poor prognosis, and limited therapeutic …

Neuroblastoma (NB) is the most common malignant tumor in infancy and most common
extracranial solid tumor in childhood. With the improvement of diagnosis and treatment, the …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

The combination of drugs targeting Ral and PI3K/AKT signaling has antitumor efficacy in
preclinical models of pancreatic cancer. We combined dinaciclib (small molecule cyclin …

Abstract Magnesium ion (Mg2+) has received increased attention due to the roles it plays in
promoting osteogenesis and preventing inflammation. This study was designed to …