Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for
treating various diseases, with nearly 70 FDA approvals specifically for cancer treatment …

In our study, a series of quinazoline-1, 2, 3-triazole hybrids (14a-r) have been designed and
synthesized as multi-target EGFR, VEGFR-2, and Topo II inhibitors. All synthesized hybrids …

Triple-negative breast cancer (TNBC) comprises 10% to 20% of breast cancer, however, it is
more dangerous than other types of breast cancer, because it lacks druggable targets, such …

Herein, we outline a highly efficient PEG‐4000‐mediated one‐pot three‐component
reaction for the synthesis of 3‐imidazolyl indole clubbed 1, 2, 3‐triazole derivatives (5a–r) at …

Sixteen new 2-substituted quinazolines were synthesized using a straightforward
methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid. The anti …

In this work, the cyclocondensation reaction mechanism between methyl 2-amino-4-(2-
diethylaminoethoxy)-5-methoxybenzoate (MAD, 1) and formamide (FME, 2) was …

Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has
earned considerable attention due to its importance in the field of medicinal chemistry. The …

The alkylation reaction was used to couple zerumbone with the 3-substituted quinazolinone-
4 (3H)-ones and quinolines, resulting in the formation of 11 new conjugates. Their structures …

Most of the current chemotherapeutic medications are extremely toxic, exhibit little
selectivity, and contribute to the emergence of treatment resistance. Consequently, the …