Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …

Mitochondrial ATP synthase plays a key role in inducing membrane curvature to establish
cristae. In Apicomplexa causing diseases such as malaria and toxoplasmosis, an unusual …

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria
parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both …

Toxoplasma is an obligate intracellular parasite that replicates in mammalian cells within a
parasitophorous vacuole (PV) that does not fuse with any host organelles. One mechanism …

The genome-wide identification of gene functions in malaria parasites is hampered by a lack
of reverse genetic screening methods. We present a large-scale resource of barcoded …

Toxoplasma gondii possesses sets of dense granule proteins (GRAs) that either assemble
at, or cross the parasitophorous vacuole membrane (PVM) and exhibit motifs resembling the …

Coenzyme A (CoA) biosynthesis is an excellent target for antimalarial intervention. While
most studies have focused on the use of CoA to produce acetyl-CoA in the apicoplast and …

The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full
complement of proteins that localize to this organelle has not been defined. Here we …