A neuroimmune crosstalk is involved in somatic and visceral pathological pain including
inflammatory and neuropathic components. Apart from microglia essential for spinal and …

Introduction: Most arthritides are associated with pain and psychological distress (clinically
significant depression and anxiety). Pain and depression are mutually exacerbating; both …

Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs),
therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available …

Chemotherapy-induced peripheral neuropathy (CIPN) adversely impacts quality of life and a
challenge to treat with existing drugs used for neuropathic pain. Losartan, an angiotensin II …

Background and Purpose The cytokine activin C is mainly expressed in small‐diameter
dorsal root ganglion (DRG) neurons and suppresses inflammatory pain. However, the …

Diseases of joints are among the most frequent causes of chronic pain. In the course of joint
diseases, the peripheral and the central nociceptive system develop persistent …

Background Neuropathic pain in neuroimmunological disorders refers to pain caused by a
lesion or disease of the somatosensory system such as multiple sclerosis (MS) and …

Leukocyte infiltration and persistence within peripheral nerves have been implicated in
chronic nociception pathogenesis in murine peripheral neuropathy models. Endoneurial …

Objectives: We aimed to investigate the protective potential of Punica granatum L. fruit rind
extract (PFE) containing punicalagin (10.3% W/W), ellagic acid (EA)(2.7% W/W) in …

Background Neuropathic pain is a debilitating status that is insusceptible to the existing
analgesics. It is important to explore the underlying pathophysiological changes and search …