As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Background The regulatory mechanisms involved in mitochondrial quality control (MQC)
dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized …

The Mitofusin 2 protein (MFN2), encoded by the MFN2 gene, was first described for its role
in mediating mitochondrial fusion. However, MFN2 is now recognized to play additional …

Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …

The integrity of ER–mitochondria appositions ensures transfer of ions and phospholipids
(PLs) between these organelles and exerts crucial effects on mitochondrial bioenergetics …

Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by …

Dysregulation of mitochondrial Ca2+ homeostasis has been linked to neurodegenerative
diseases. Mitochondrial Ca2+ uptake is mediated via the calcium uniporter complex that is …

Protein misfolding is prominent in early cellular pathology of Alzheimer's disease (AD),
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …