Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia

DMG Silva, C Nardiello, A Pozarska… - American Journal of …, 2015 - journals.physiology.org
Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Bronchopulmonary dysplasia: an update of current pharmacologic therapies and new approaches

Z Michael, F Spyropoulos, S Ghanta… - Clinical Medicine …, 2018 - journals.sagepub.com
Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of
surviving extremely preterm infants and is associated with significant health care utilization …

Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung …

GR Willis, A Fernandez-Gonzalez, M Reis… - Journal of …, 2020 - Taylor & Francis
Early administration of mesenchymal stromal cell (MSC)-derived small extracellular vesicles
(MEx) has shown considerable promise in experimental models of bronchopulmonary …

New BPD-prevalence and risk factors for bronchopulmonary dysplasia/mortality in extremely low gestational age infants≤ 28 weeks

O Geetha, VS Rajadurai, AJ Anand… - Journal of …, 2021 - nature.com
Objective To evaluate prevalence and risk factors of moderate-severe Bronchopulmonary
dysplasia (BPD)/Death in extremely low gestation age neonates (ELGANs). Study design …

Looking ahead: where to next for animal models of bronchopulmonary dysplasia?

C Nardiello, I Mižíková, RE Morty - Cell and Tissue Research, 2017 - Springer
Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, with
appreciable morbidity and mortality in a neonatal intensive care setting. Much interest has …

The future of bronchopulmonary dysplasia: emerging pathophysiological concepts and potential new avenues of treatment

JJP Collins, D Tibboel, IM de Kleer, IKM Reiss… - Frontiers in …, 2017 - frontiersin.org
Yearly more than 15 million babies are born premature (< 37 weeks gestational age),
accounting for more than 1 in 10 births worldwide. Lung injury caused by maternal …

The effect of gender on mesenchymal stem cell (MSC) efficacy in neonatal hyperoxia-induced lung injury

I Sammour, S Somashekar, J Huang, S Batlahally… - PLoS …, 2016 - journals.plos.org
Background Mesenchymal stem cells (MSC) improve alveolar and vascular structures in
experimental models of bronchopulmonary dysplasia (BPD). Female MSC secrete more anti …

Bronchopulmonary dysplasia

E Bancalari, T Gerhardt - Pediatric Clinics of North America, 1986 - Elsevier
Bronchopulmonary dysplasia has become the most common pulmonary sequelae in
neonates receiving mechanical ventilation. The pathogenesis of BPD is multifactorial, but …

Preventing bronchopulmonary dysplasia: new tools for an old challenge

M Álvarez-Fuente, L Moreno, JA Mitchell, IK Reiss… - Pediatric …, 2019 - nature.com
Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in infants
and presents as a consequence of preterm birth. Due to the lack of effective preventive and …

Defining the risk and associated morbidity and mortality of severe respiratory syncytial virus infection among infants with chronic lung disease

B Paes, B Fauroux, J Figueras-Aloy, L Bont… - Infectious diseases and …, 2016 - Springer
Abstract Introduction The REGAL (RSV evidence—a geographical archive of the literature)
series provide a comprehensive review of the published evidence in the field of respiratory …