Permeability glycoprotein (P-gp) mediates the export of drugs from cells located in the small
intestine, blood-brain barrier, hepatocytes, and kidney proximal tubule, serving a protective …

The antituberculosis drug rifampicin (rifampin) induces a number of drug-metabolising
enzymes, having the greatest effects on the expression of cytochrome P450 (CYP) 3A4 in …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. On the
basis of clinical observations of patients in whom digoxin levels decreased considerably …

Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance
against antineoplastic agents but also plays an important role in the bioavailability of …

In humans, there are two P-glycoprotein (P-gp) transporters encoded by MDR1 (PGY1) and
MDR3 (also named MDR2 and PGY3) adjacently located at the chromosomal region 7q21 …

Gut microbiota, one of the determinants of pharmacokinetics, has long been underestimated.
It is now generally accepted that the gut microbiota plays an important role in drug …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

Background—Although quinidine is known to elevate plasma digoxin concentrations, the
mechanism underlying this interaction is not fully understood. Digoxin is not extensively …

CYP3A4 present in small bowel enterocytes can catalyze substantial metabolism of some
orally administered drugs and, thus, exerts a first-pass effect. Recent data indicate that the P …