Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the
neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations …

In the present review different aspects related to the essential element selenium in the
human organism are considered. A large number of human studies have been performed in …

Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities
during development and early adulthood, but had a reduced lifespan and increased …

Oxidative stress is a common pathogenetic mechanism contributing to initiation and
progression of hepatic damage in a variety of liver disorders. Cell damage occurs when …

Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple
genetic aberrations. Several molecular pathways involved in the regulation of proliferation …

Abstract Development of hepatocellular carcinoma (HCC) is accompanied by a continuous
increase in reactive oxygen species (ROS) levels. To investigate the primary source of ROS …

Obesity and insulin resistance are considered the main causes of nonalcoholic fatty liver
disease (NAFLD), and oxidative stress accelerates the progression of NAFLD. Free fatty …

We investigated glutathione level, activities of selenium independent GSH peroxidase,
selenium dependent GSH peroxidase, GSH S-transferase, GSH reductase and the rate of …

In this review, the role of dietary antioxidants in the prevention of hepatocarcinogenesis is
examined. Both human and animal models are discussed. Vitamin C, vitamin E, and …

Recently carbon nanotubes (CNTs) showed promising potentials in different biomedical
applications but their safe use in humans and probable toxicities are still challenging. The …