[HTML][HTML] The continued threat of emerging flaviviruses

TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines

D Ruzek, TA Županc, J Borde, A Chrdle, L Eyer… - Antiviral Research, 2019 - Elsevier
Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …

[HTML][HTML] Broad-spectrum antiviral strategies and nucleoside analogues

RJ Geraghty, MT Aliota, LF Bonnac - Viruses, 2021 - mdpi.com
The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such
as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory …

A critical review on environmental presence of pharmaceutical drugs tested for the covid-19 treatment

RP Nippes, PD Macruz, GN da Silva… - Process Safety and …, 2021 - Elsevier
Abstract On March 11, 2020, the World Health Organization (WHO) declared COVID-19 a
pandemic. The outbreak caused a worldwide impact, becoming a health threat to the …

[HTML][HTML] Current trends and limitations in dengue antiviral research

JO Obi, H Gutiérrez-Barbosa, JV Chua… - Tropical Medicine and …, 2021 - mdpi.com
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

Potential therapeutic agents for COVID-19 based on the analysis of protease and RNA polymerase docking

YC Chang, YA Tung, KH Lee, TF Chen, YC Hsiao… - 2020 - preprints.org
The outbreak of novel coronavirus (COVID-19) infections in 2019 is in dire need of finding
potential therapeutic agents. In this study, we used molecular docking to repurpose HIV …

[HTML][HTML] Plasmin and plasminogen system in the tumor microenvironment: implications for cancer diagnosis, prognosis, and therapy

AG Bharadwaj, RW Holloway, VA Miller, DM Waisman - Cancers, 2021 - mdpi.com
Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

[HTML][HTML] Antiviral and antimicrobial nucleoside derivatives: structural features and mechanisms of action

AA Zenchenko, MS Drenichev, IA Il'Icheva… - Molecular biology, 2021 - Springer
The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response

Y Ariav, JH Ch'ng, HR Christofk, N Ron-Harel… - Science advances, 2021 - science.org
Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …

[HTML][HTML] Nucleoside analogs and nucleoside precursors as drugs in the fight against SARS-CoV-2 and other coronaviruses

N Borbone, G Piccialli, GN Roviello, G Oliviero - Molecules, 2021 - mdpi.com
Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family
Coronaviridae, that cause infections in a broad range of mammals including humans …