Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP) are
chronic respiratory diseases. These two disorders often co-exist based on common …

The strong anti-inflammatory and immunosuppressive effects of glucocorticoids are
mediated primarily by the cytosolic glucocorticoid receptors. These receptors are members …

Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …

Inflammatory lung diseases are characterised by increased expression of multiple
inflammatory genes that are regulated by proinflammatory transcription factors, such as …

There has been a recent increase in the prevalence of asthma worldwide; however, the 5–
10% of patients with severe disease account for a substantial proportion of the health costs …

Corticosteroids are the most effective anti-inflammatory therapy for asthma. Inflammation in
asthma is characterised by the increased expression of multiple inflammatory genes …

Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive
drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory
diseases, inhibit the expression of many inflammatory mediators. They can also induce the …

Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …