Molecular genetics of Dupuytren's contracture

S Aissvarya, KH Ling, M Arumugam… - EFORT Open …, 2024 - eor.bioscientifica.com
Dupuytren's contracture (DC) is a fibroproliferative disorder of the palmar fascia
characterised by the digits' flexion contractures and is associated with abnormal build-up of …

Alterations in the Structure, Composition, and Organization of Galactosaminoglycan-Containing Proteoglycans and Collagen Correspond to the Progressive Stages of …

LGS Lenzi, JB Gomes dos Santos… - International Journal of …, 2024 - mdpi.com
Dupuytren's disease (DD) is a prevalent fibroproliferative disorder of the hand, shaped by
genetic, epigenetic, and environmental influences. The extracellular matrix (ECM) is a …

Generation and evaluation of novel biomaterials based on decellularized sturgeon cartilage for use in tissue engineering

O Ortiz-Arrabal, R Carmona, ÓD García-García… - Biomedicines, 2021 - mdpi.com
Because cartilage has limited regenerative capability, a fully efficient advanced therapy
medicinal product is needed to treat severe cartilage damage. We evaluated a novel …

Biochemical and Histological Differences between Longitudinal and Vertical Fibres of Dupuytren's Palmar Aponeurosis and Innovative Clinical Implications

C Fede, L Coldebella, L Petrelli, F Bassetto… - International Journal of …, 2024 - mdpi.com
Dupuytren's disease, a chronic and progressive fibroproliferative lesion of the hand, which
affects the palmar fascia, has a recurrence rate after selective aponeurotomy of 20–40% at 5 …

Fibrosis-associated signaling molecules are differentially expressed in palmar connective tissues of patients with carpal tunnel syndrome and Dupuytren's disease

I Tripković, M Ogorevc, D Vuković, M Saraga-Babić… - Biomedicines, 2022 - mdpi.com
Carpal tunnel syndrome (CTS) and Dupuytren's disease (DD) are fibrotic conditions that
affect the connective tissue of the hand and limit its functionality. The exact molecular …

Proteomic Analysis of Dupuytren's Contracture-Derived Sweat Glands Revealed the Synthesis of Connective Tissue Growth Factor and Initiation of Epithelial …

CG Cárdenas-León, K Mäemets-Allas, M Klaas… - International Journal of …, 2023 - mdpi.com
Dupuytren's contracture (DC) is a chronic and progressive fibroproliferative disorder
restricted to the palmar fascia of the hands. Previously, we discovered the presence of high …

Integrative genomic and transcriptomic analysis of genetic markers in Dupuytren's disease

J Jung, GW Kim, B Lee, JWJ Joo, W Jang - BMC Medical Genomics, 2019 - Springer
Background Dupuytren's disease (DD) is a fibroproliferative disorder characterized by
thickening and contracting palmar fascia. The exact pathogenesis of DD remains unknown …

Evaluation of freeze‐drying and cryopreservation protocols for long‐term storage of biomaterials based on decellularized intestine

E Díaz‐Moreno, D Durand‐Herrera… - … Research Part B …, 2018 - Wiley Online Library
We evaluated the efficiency of several protocols to preserve the main components of
decellularized tissue scaffolds for delayed use. Decellularized rat intestine scaffolds were …

Usefulness of a nanostructured fibrin-agarose bone substitute in a model of severely critical mandible bone defect

MA Martin-Piedra, B Gironés-Camarasa… - Polymers, 2021 - mdpi.com
Critical defects of the mandibular bone are very difficult to manage with currently available
materials and technology. In the present work, we generated acellular and cellular …

Needle biopsy‐derived myofascial tissue samples are sufficient for quantification of myofibroblast density

R Schleip, J Wilke, S Schreiner, M Wetterslev… - Clinical …, 2018 - Wiley Online Library
Quantification of myofibroblasts is a promising method for assessing tissue properties in the
field of fascia research. This is commonly performed by immunohistochemistry for α‐smooth …