Effects and mechanisms of resveratrol on aging and age‐related diseases

DD Zhou, M Luo, SY Huang, A Saimaiti… - Oxidative medicine …, 2021 - Wiley Online Library
The aging of population has become an issue of great concern because of its rapid
increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be …

Diet and male fertility: the impact of nutrients and antioxidants on sperm energetic metabolism

A Ferramosca, V Zara - International journal of molecular sciences, 2022 - mdpi.com
Diet might affect male reproductive potential, but the biochemical mechanisms involved in
the modulation of sperm quality remain poorly understood. While a Western diet is …

Resveratrol inhibited the metastatic behaviors of cisplatin‐resistant human oral cancer cells via phosphorylation of ERK/p‐38 and suppression of MMP‐2/9

WS Chang, CW Tsai, JS Yang, YM Hsu… - Journal of Food …, 2021 - Wiley Online Library
Cisplatin resistance is a major clinical problem in the clinical management of oral squamous
cell carcinoma (OSCC) patients. Resveratrol is a natural phytoestrogen with antitumor …

Resveratrol and immune cells: a link to improve human health

A Alesci, N Nicosia, A Fumia, F Giorgianni, A Santini… - Molecules, 2022 - mdpi.com
The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases
has been investigated in recent years due to their possible antioxidant action. Polyphenols …

Oxidative stress and oocyte cryopreservation: recent advances in mitigation strategies involving antioxidants

B Cao, J Qin, B Pan, IH Qazi, J Ye, Y Fang, G Zhou - Cells, 2022 - mdpi.com
Oocyte cryopreservation is widely used in assisted-reproductive technology and animal
production. However, cryopreservation not only induces a massive accumulation of reactive …

Hallmarks of testicular aging: the challenge of anti-inflammatory and antioxidant therapies using natural and/or pharmacological compounds to improve the …

ME Matzkin, RS Calandra, SP Rossi, A Bartke… - Cells, 2021 - mdpi.com
The evolutionary theory of aging supports a trade-off relationship between reproduction and
aging. Aging of the male reproductive system primarily affects the testes, leading to a …

Resveratrol and reproductive health

R Novakovic, J Rajkovic, M Gostimirovic… - Life, 2022 - mdpi.com
Resveratrol (RSV), a plant-derived polyphenol, demonstrates broad-spectrum health
benefits, including anti-proliferative, anti-inflammatory, antidiabetic, anti-ischemic and …

Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state

Y Yang, L Shi, X Fu, G Ma, Z Yang, Y Li, Y Zhou… - PLoS …, 2022 - journals.plos.org
Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction
between the 3-to 8-cell stage, posing a significant clinical problem. The mechanisms behind …

Resveratrol in the hypothalamic paraventricular nucleus attenuates hypertension by regulation of ROS and neurotransmitters

J Qi, LY Fu, KL Liu, RJ Li, JA Qiao, XJ Yu, JY Yu, Y Li… - Nutrients, 2022 - mdpi.com
Background: The hypothalamic paraventricular nucleus (PVN) is an important nucleus in the
brain that plays a key role in regulating sympathetic nerve activity (SNA) and blood pressure …

The Ameliorating Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are SIRT1-Dependent: Evidence from Hepatic-Specific SIRT1 …

Y Yin, D Li, F Liu, X Wang, Y Cui, S Li… - Journal of Agricultural …, 2022 - ACS Publications
Apple polyphenol extract (APE) has been reported to possess protective effects against
hepatic steatosis. To explore whether APE-induced alleviation of hepatic steatosis is SIRT1 …