Heterogeneity in astrocyte morphology and physiology

V Matyash, H Kettenmann - Brain research reviews, 2010 - Elsevier
Astrocytes as a cell population are not well defined and comprise a heterogeneous
population of cells. There are at least 9 different morphological variants which can coexist …

Drowning stars: reassessing the role of astrocytes in brain edema

AS Thrane, VR Thrane, M Nedergaard - Trends in neurosciences, 2014 - cell.com
Edema formation frequently complicates brain infarction, tumors, and trauma. Despite the
significant mortality of this condition, current treatment options are often ineffective or …

Uniquely hominid features of adult human astrocytes

NA Oberheim, T Takano, X Han, W He… - Journal of …, 2009 - Soc Neuroscience
Defining the microanatomic differences between the human brain and that of other
mammals is key to understanding its unique computational power. Although much effort has …

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

V Benfenati, M Caprini, M Dovizio… - Proceedings of the …, 2011 - National Acad Sciences
Regulatory volume decrease (RVD) is a key mechanism for volume control that serves to
prevent detrimental swelling in response to hypo-osmotic stress. The molecular basis of …

[HTML][HTML] Astroglia in dementia and Alzheimer's disease

JJ Rodriguez, M Olabarria, A Chvatal… - Cell Death & …, 2009 - nature.com
Astrocytes, the most numerous cells in the brain, weave the canvas of the grey matter and
act as the main element of the homoeostatic system of the brain. They shape the …

Loss of astrocytic domain organization in the epileptic brain

NA Oberheim, GF Tian, X Han, W Peng… - Journal of …, 2008 - Soc Neuroscience
Gliosis is a pathological hallmark of posttraumatic epileptic foci, but little is known about
these reactive astrocytes beyond their high glial fibrillary acidic protein (GFAP) expression …

Complex and region-specific changes in astroglial markers in the aging brain

JJ Rodríguez, CY Yeh, S Terzieva, M Olabarria… - Neurobiology of …, 2014 - Elsevier
Morphological aging of astrocytes was investigated in entorhinal cortex (EC), dentate gyrus
(DG), and cornu ammonis 1 (CA1) regions of hippocampus of male SV129/C57BL6 mice of …

Real‐time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices and in vivo revealed by two‐photon microscopy

WC Risher, RD Andrew, SA Kirov - Glia, 2009 - Wiley Online Library
The brain swells over the several minutes that follow stroke onset or acute hypo-osmotic
stress because cells take up water. Measuring the volume responses of single neurons and …

Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease

M Kulijewicz‐Nawrot, A Verkhratsky… - Journal of …, 2012 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
loss of cognitive functions, reflecting pathological damage to the medial prefrontal cortex …

Insights into brain microstructure from in vivo DW-MRS

M Palombo, N Shemesh, I Ronen, J Valette - Neuroimage, 2018 - Elsevier
Many developmental processes, such as plasticity and aging, or pathological processes
such as neurological diseases are characterized by modulations of specific cellular types …