Microbial proteases applications

A Razzaq, S Shamsi, A Ali, Q Ali, M Sajjad… - … in bioengineering and …, 2019 - frontiersin.org
The use of chemicals around the globe in different industries has increased tremendously,
affecting the health of people. The modern world intends to replace these noxious chemicals …

Nutrition and sarcopenia—what do we know?

A Ganapathy, JW Nieves - Nutrients, 2020 - mdpi.com
Muscle health is important for the functionality and independence of older adults, and certain
nutrients as well as dietary patterns have been shown to offer protective effects against …

[HTML][HTML] A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

DM Anderson, KM Anderson, CL Chang… - Cell, 2015 - cell.com
Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

Engineering human pluripotent stem cells into a functional skeletal muscle tissue

L Rao, Y Qian, A Khodabukus, T Ribar… - Nature …, 2018 - nature.com
The generation of functional skeletal muscle tissues from human pluripotent stem cells
(hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) …

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

M Okada-Iwabu, T Yamauchi, M Iwabu, T Honma… - Nature, 2013 - nature.com
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2,
and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively …

Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

M Dos Santos, S Backer, B Saintpierre, B Izac… - Nature …, 2020 - nature.com
Skeletal muscle fibers are large syncytia but it is currently unknown whether gene
expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq …

Exercise attenuates the major hallmarks of aging

N Garatachea, H Pareja-Galeano… - Rejuvenation …, 2015 - liebertpub.com
Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Bio-inspired track-etched polymeric nanochannels: steady-state biosensors for detection of analytes

J Wang, Y Zhou, L Jiang - ACS nano, 2021 - ACS Publications
Bio-inspired polymeric nanochannel (also referred as nanopore)-based biosensors have
attracted considerable attention on account of their controllable channel size and shape …

The sick and the weak: neuropathies/myopathies in the critically ill

O Friedrich, MB Reid, G Van den Berghe… - Physiological …, 2015 - journals.physiology.org
Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

H Xu, H Van Remmen - Skeletal Muscle, 2021 - Springer
As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …