Diffusion tensor imaging in amyotrophic lateral sclerosis: machine learning for biomarker development

A Behler, HP Müller, AC Ludolph… - International journal of …, 2023 - mdpi.com
Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Biomarkers in amyotrophic lateral sclerosis: current status and future prospects

R McMackin, P Bede, C Ingre, A Malaspina… - Nature Reviews …, 2023 - nature.com
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

[HTML][HTML] Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in spinal muscular atrophy and amyotrophic lateral sclerosis

C Deng, H Chen - Neurobiology of Disease, 2023 - Elsevier
Tropomyosin receptor kinase B (TrkB) and its primary ligand brain-derived neurotrophic
factor (BDNF) are expressed in the neuromuscular system, where they affect neuronal …

Current potential diagnostic biomarkers of amyotrophic lateral sclerosis

Z Xu, R Xu - Reviews in the Neurosciences, 2024 - degruyter.com
Amyotrophic lateral sclerosis (ALS) currently lacks the useful diagnostic biomarkers. The
current diagnosis of ALS is mainly depended on the clinical manifestations, which …

PET imaging in dementia: Mini-review and Canadian perspective for clinical use

F Juengling, F Wuest, R Schirrmacher… - Canadian Journal of …, 2024 - cambridge.org
PET imaging is increasingly recognized as an important diagnostic tool to investigate
patients with 25 cognitive disturbances of possible neurodegenerative origin. PET with 2 …