The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Probiotics and gut microbiota: Mechanistic insights into gut immune homeostasis through TLR pathway regulation

H Kaur, SA Ali - Food & Function, 2022 - pubs.rsc.org
Consumption of probiotics as a useful functional food improves the host's wellbeing, and,
when paired with prebiotics (indigestible dietary fibre/carbohydrate), often benefits the host …

Promising role of defensins peptides as therapeutics to combat against viral infection

SS Solanki, P Singh, P Kashyap, MS Sansi… - Microbial pathogenesis, 2021 - Elsevier
Antimicrobial peptides (AMPs) are ubiquitously present small peptides, which play a critical
function in the innate immune system. The defensin class of AMPs represented an …

Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens

X Liao, Y Lan, W Wang, J Zhang, R Shao, Z Yin… - Gut …, 2023 - Taylor & Francis
Although evidence has shown that vitamin D (VD) influences gut homeostasis, limited
knowledge is available how VD regulates intestinal immunity against bacterial infection. In …

Resistin, a novel host defense peptide of innate immunity

Y Li, Q Yang, D Cai, H Guo, J Fang, H Cui… - Frontiers in …, 2021 - frontiersin.org
Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link
between obesity and diabetes in mice. In humans, resistin is considered to be a pro …

Cathelicidin LL-37 in health and diseases of the oral cavity

J Tokajuk, P Deptuła, E Piktel, T Daniluk… - Biomedicines, 2022 - mdpi.com
The mechanisms for maintaining oral cavity homeostasis are subject to the constant
influence of many environmental factors, including various chemicals and microorganisms …

[HTML][HTML] Targeting mitochondrial ion channels for cancer therapy

I Szabo, M Zoratti, L Biasutto - Redox Biology, 2021 - Elsevier
Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Immunomodulatory properties of host defence peptides in skin wound healing

M Petkovic, MV Mouritzen, B Mojsoska, H Jenssen - Biomolecules, 2021 - mdpi.com
Cutaneous wound healing is a vital biological process that aids skin regeneration upon
injury. Wound healing failure results from persistent inflammatory conditions observed in …

Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology

G Maubach, M Vieth, F Boccellato… - Trends in Molecular …, 2022 - cell.com
NF-κB signaling pathways, induced by a variety of triggers, play a key role in regulating the
expression of genes involved in the immune response and cellular responses to stress. The …