Natriuretic peptides

LB Daniels, AS Maisel - Journal of the American college of cardiology, 2007 - jacc.org
Natriuretic peptides (NPs) are released from the heart in response to pressure and volume
overload. B-type natriuretic peptide (BNP) and N-terminal-proBNP have become important …

Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics

S Mangiafico, LC Costello-Boerrigter… - European heart …, 2013 - academic.oup.com
Hypertension and heart failure (HF) are common diseases that, despite advances in medical
therapy, continue to be associated with high morbidity and mortality. Therefore, innovative …

BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME …

M Pfisterer, P Buser, H Rickli, M Gutmann, P Erne… - Jama, 2009 - jamanetwork.com
Context It is uncertain whether intensified heart failure therapy guided by N-terminal brain
natriuretic peptide (BNP) is superior to symptom-guided therapy. Objective To compare 18 …

N-terminal–pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients

P Bettencourt, A Azevedo, J Pimenta, F Friões… - Circulation, 2004 - Am Heart Assoc
Background—Heart failure (HF) is responsible for a huge burden in hospital care. Our goal
was to evaluate the value of N-terminal–pro-brain natriuretic peptide (NT-proBNP) in …

National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: clinical utilization of cardiac biomarker testing in heart failure

WH Wilson Tang, GS Francis, DA Morrow, LK Newby… - Circulation, 2007 - Am Heart Assoc
Biochemical marker testing has revolutionized the approach to diagnosis and management
of heart failure over the past decade. There is an unsurpassed excitement in the heart failure …

Cardiac hormones as diagnostic tools in heart failure

H Ruskoaho - Endocrine reviews, 2003 - academic.oup.com
In patients with heart failure, plasma levels of atrial natriuretic peptide (ANP), B-type
natriuretic peptide (BNP), and the N-terminal fragments of their prohormones (N-ANP and N …

Clinical applications of B-type natriuretic peptide (BNP) testing

MR Cowie, P Jourdain, A Maisel… - European heart …, 2003 - academic.oup.com
Many claims have been made in recent years regarding the utility of plasma B-type
natriuretic peptide (BNP) concentration measurements in the diagnosis, risk stratification …

Candidate‐based proteomics in the search for biomarkers of cardiovascular disease

L Anderson - The Journal of physiology, 2005 - Wiley Online Library
The key concept of proteomics (looking at many proteins at once) opens new avenues in the
search for clinically useful biomarkers of disease, treatment response and ageing. As the …

A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: a multicenter evaluation

SJ Wieczorek, AHB Wu, R Christenson… - American heart …, 2002 - Elsevier
Background B-Type natriuretic peptide (BNP), a protein released from the left ventricle in
response to volume expansion and pressure overload, has emerged as the first whole blood …

Plasma B-type natriuretic peptide levels in ambulatory patients with established chronic symptomatic systolic heart failure

WHW Tang, JP Girod, MJ Lee, RC Starling, JB Young… - Circulation, 2003 - Am Heart Assoc
Background—The diagnostic and prognostic values of plasma B-type natriuretic peptide
(BNP) testing are established. However, the range of plasma BNP levels present in the …