Angiotensinogen (AGT) is the unique precursor of all angiotensin peptides. Many of the
basic understandings of AGT in cardiovascular diseases have come from research efforts to …

The history of the renin angiotensin system (RASa) traces its roots to the seminal
experiments of Tigerstedt and Bergman describing a pressor response in the rabbit …

Longan is an ancient and popular plant with highly nutritious fruit. The pulp is the main part
of the fruit which is consumed. However, the potentials of other longan fruit parts such as the …

Background Blockade of the renin–angiotensin–aldosterone system (RAAS) at its rate-
limiting step by means of renin inhibition has led to the development of direct renin inhibitors …

Introduction Anticoagulant‐related nephropathy (ARN), that was described in humans first
as warfarin‐related nephropathy, is characterized by acute kidney injury and red blood cell …

Importance of the field: The renin-angiotensin-aldosterone system (RAAS) is a key regulator
of blood pressure (BP), as well as volume and electrolytes, in both hypertensive and …

Renin has been recognized as an attractive target for antihypertensive drugs since the
1950s. Intensive efforts in the 1980s focused on peptidomimetic hydroxy transition‐state …

肾素-血管紧张素-醛固酮系统是药物治疗心血管系统疾病的关键作用靶点. 阻断肾素-
血管紧张素系统的病理生理作用可以从三个位点进行: 血管紧张素转换酶抑制剂, 血管紧张素Ⅱ …

SUMMARY 1 Hypertensive mice expressing the human renin (REN) and angiotensinogen
(AGT) genes are used as a model for human hypertension. 2 The aim of the present study …