Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Aging and neurodegenerative disease: is the adaptive immune system a friend or foe?

K Mayne, JA White, CE McMurran, FJ Rivera… - Frontiers in aging …, 2020 - frontiersin.org
Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

The role of gamma-delta T cells in diseases of the central nervous system

J Wo, F Zhang, Z Li, C Sun, W Zhang… - Frontiers in …, 2020 - frontiersin.org
Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of
lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy - Pharmacological reviews, 2022 - ASPET
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Multipotential and systemic effects of traumatic brain injury

N Sabet, Z Soltani, M Khaksari - Journal of neuroimmunology, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of disability and mortality of people
at all ages. Biochemical, cellular and physiological events that occur during primary injury …

Overview of traumatic brain injury: an immunological context

D Nizamutdinov, LA Shapiro - Brain sciences, 2017 - mdpi.com
Traumatic brain injury (TBI) afflicts people of all ages and genders, and the severity of injury
ranges from concussion/mild TBI to severe TBI. Across all spectrums, TBI has wide-ranging …

[HTML][HTML] White matter damage after traumatic brain injury: a role for damage associated molecular patterns

M Braun, K Vaibhav, NM Saad, S Fatima… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …

Neuropathophysiological mechanisms and treatment strategies for post-traumatic epilepsy

S Sharma, G Tiarks, J Haight… - Frontiers in molecular …, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a leading cause of death in young adults and a risk factor for
acquired epilepsy. Severe TBI, after a period of time, causes numerous neuropsychiatric and …

Brain trauma, glucocorticoids and neuroinflammation: dangerous liaisons for the hippocampus

IG Komoltsev, NV Gulyaeva - Biomedicines, 2022 - mdpi.com
Glucocorticoid-dependent mechanisms of inflammation-mediated distant hippocampal
damage are discussed with a focus on the consequences of traumatic brain injury. The …

Platelet-to-lymphocyte ratio predicts short-term mortality in patients with moderate to severe traumatic brain injury

W Li, W Deng - Scientific Reports, 2022 - nature.com
An easily accessible biomarker with good diagnostic power for patients with traumatic brain
injury (TBI) was needed to predict the short-term mortality. Studies have shown that platelet …