DNA Adducts in Cancer Chemotherapy
Y Li - Journal of Medicinal Chemistry, 2024 - ACS Publications
DNA adducting drugs, including alkylating agents and platinum-containing drugs, are
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …
Anthracyclines react with apurinic/apyrimidinic sites in DNA
M Bellamri, JT Terrell, K Brandt, F Gruppi… - ACS chemical …, 2023 - ACS Publications
The combination of doxorubicin (Adriamycin) and cyclophosphamide, referred to as AC
chemotherapy, is commonly used for the clinical treatment of breast and other cancers. Both …
chemotherapy, is commonly used for the clinical treatment of breast and other cancers. Both …
[HTML][HTML] Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices
Nitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung
injury which can progress to chronic disease. Due to the complex nature of NM injury, it has …
injury which can progress to chronic disease. Due to the complex nature of NM injury, it has …
Liquid Chromatography–Mass Spectrometry Screening of Cyclophosphamide DNA Damage In Vitro and in Patients Undergoing Chemotherapy Treatment
DNA alkylating drugs have been used as frontline medications to treat cancer for decades.
Their chemical reaction with DNA leads to the blockage of DNA replication, which impacts …
Their chemical reaction with DNA leads to the blockage of DNA replication, which impacts …
Interaction of mitoxantrone with abasic sites-DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
IG Minko, SA Moellmer, MM Luzadder, R Tomar… - DNA repair, 2024 - Elsevier
Abstract Mitoxantrone (1, 4-dihydroxy-5, 8-bis [2-(2-hydroxyethylamino) ethylamino]-
anthracene-9, 10-dione) is a clinically-relevant synthetic anthracenedione that functions as a …
anthracene-9, 10-dione) is a clinically-relevant synthetic anthracenedione that functions as a …
[HTML][HTML] Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems
SC Krassnig, M Mäser, NA Probst, J Werner, C Schlett… - Toxicology Reports, 2023 - Elsevier
Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly
reactive bifunctional alkylating agents and were the first chemotherapeutic agents …
reactive bifunctional alkylating agents and were the first chemotherapeutic agents …
In Vitro Evaluation of DNA Damage Effect Markers toward Five Nitrogen Mustards Based on Liquid Chromatography–Tandem Mass Spectrometry
K Li, Z Li, J Wu, Y Gong, L Guo… - Chemical Research in …, 2021 - ACS Publications
Endogenous DNA lesions frequently occur due to internal effects such as oxidative stress,
inflammation, endogenous alkylation, and epigenetic modifications. However, exposure to …
inflammation, endogenous alkylation, and epigenetic modifications. However, exposure to …
A base-repair based electrochemiluminescent genotoxicity sensor that detects abasic sites in double-stranded DNA films
DM Wang, J Jia, RF Huang, X Zhang - Chemical Communications, 2020 - pubs.rsc.org
A novel genotoxicity sensor was developed based on the base repair process associated
with the electrochemiluminescence (ECL) detection of abasic sites in a double-stranded …
with the electrochemiluminescence (ECL) detection of abasic sites in a double-stranded …
DNA 脱碱基位点的检测方法及其生物学研究进展
武海江， 张雅姣， 袁舒妍， 徐华， 谢剑炜 - 分析测试学报, 2023 - fxcsxb.com
DNA 中糖苷键断裂形成的脱碱基位点(脱嘌呤/嘧啶位点, AP 位点) 是常见的DNA 损伤类型之一,
由核苷酸自发水解产生, 也是DNA 碱基切除修复途径中的关键中间体. 若修复不及时 …
由核苷酸自发水解产生, 也是DNA 碱基切除修复途径中的关键中间体. 若修复不及时 …
[HTML][HTML] 氮芥与DNA 体外加合物及其质谱裂解规律
王朝霞， 刘玉龙， 陈佳， 刘艳芹， 徐华， 谢剑炜 - 分析测试学报, 2024 - fxcsxb.com
氮芥作为两用物质, 不仅是禁止化学武器公约清单物, 其衍生物至今仍是临床化疗药物.
该文应用高效液相色谱-四极杆静电场轨道阱高分辨质谱法分析并鉴定了3 种典型氮芥(HN1 …
该文应用高效液相色谱-四极杆静电场轨道阱高分辨质谱法分析并鉴定了3 种典型氮芥(HN1 …