Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …

Outcomes of neonatal encephalopathy (NE) have improved since the widespread
implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE …

Seizures are the most common neurological emergencies in the neonatal period and are
associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 …

Although seizures have a higher incidence in neonates than any other age group and are
associated with significant mortality and neurodevelopmental disability, treatment is largely …

Therapeutic hypothermia is the only treatment currently recommended for moderate or
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …

Knowledge about the safe and effective use of medicines in neonates has increased
substantially but has resulted in few label changes. Drugs developed for use in adults are …

The availability of licensed paediatric drugs is lagging behind those for adults, and there is a
lack of safe formulations in suitable doses that children are able and willing to take. As a …

Seizures occur more often during the neonatal period than at any other period of life. Precise
incidence is difficult to delineate and depends on study population and criteria used for …

Neuroprotective controlled therapeutic hypothermia is the standard of care for newborns
suffering perinatal asphyxia. Antibiotic drugs, such as amikacin, gentamicin, and …

Background: Phenobarbital and midazolam are commonly used drugs in (near-) term
neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for …