Abstract The interleukin (IL)-1 family of cytokines comprises 11 members, including 7 pro-
inflammatory agonists (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) and 4 defined or …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Familial Mediterranean fever (FMF) is the most frequent hereditary inflammatory disease
characterized by self-limited recurrent attacks of fever and serositis. It is transmitted in an …

Objective Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by
circulation and influx of high number of polymorphonuclear neutrophils (PMN) in the affected …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

Objectives FMF is the most common periodic fever syndrome, characterized by recurrent
episodes of fever and serosal inflammation accompanied with high acute phase reactants …

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically
restricted and commonly found among individuals of Mediterranean descent, caused by …

Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of
autoinflammation, which is characterized by the episodes of fever and serositis. It affects the …

Mutations in the MEFV gene, which encodes the protein named pyrin (also called
marenostrin or TRIM20), are associated with the autoinflammatory disease familial …

Neutrophils are innate immune phagocytes that play a key role in immune defense against
invading pathogens. The main offensive mechanisms of neutrophils are the phagocytosis of …