Temporal and spatial mechanical cues play an important role in heart development,
function, and disease manifestation. A deeper understanding of cardiac mechanobiology is …

In vitro cardiac fibrosis models that monitor fibrotic markers have been developed to better
understand fibrotic progression in humans. However, these platforms lack the ability to non …

Methods................................................................................................................. 45
Results.................................................................................................................... 47 …

Volume overload (VO) induced heart failure results from an increase in blood volume
(preload) to the heart. The heart responds to increases in hemodynamic load through …

Les arythmies cardiaques représentent environ 50% des maladies cardiovasculaires qui
sont la première cause de mortalité dans le monde. Les implants médicaux jouent un rôle …

This chapter describes techniques to create functional Three-Dimensional (3-D) human cell
cultures. It discusses micro-engineered, microfluidic systems designed to contain these …

Myocardial infarction (MI) results in scarring that is essential for mechanical reinforcement of
the damaged wall. At later times however, progressive fibrosis of adjoining tissue contributes …

Hereditary fibrosing poikiloderma is an autosomal dominant disorder that is characterised by
mottled pigmentation and telangiectasia, accompanied by tendon contractures, myopathy …

Cardiac arrhythmias represent about 50% of the cardiovascular diseases which are the first
cause of mortality in the world. Implantable medical devices play a major role for treating …

The tumor microenvironment is a complex space consisting of a number of stimuli such as:
stromal cells, signaling and paracrine factors, as well as extracellular matrix (ECM) …