Infantile spasms is a severe epileptic encephalopathy of infancy. The fundamental cause is
unknown, although a number of predisposing conditions are recognized. In this article, the …

The efficacy of ACTH, particularly in high doses, for rapid and complete elimination of
infantile spasms (IS) has been demonstrated in prospective controlled studies. However, the …

Objective. The objective of this study was to determine whether the ketogenic diet is safe,
well-tolerated, and efficacious in the treatment of infantile spasms. Methods. During a 4-year …

Previous studies have shown that early life stress in the form of intermittent maternal
separation (MS) predisposes adult rats to develop stress-induced intestinal mucosal …

The hormone corticotropin (ACTH) is employed as therapy for diverse neurological
disorders, but the mechanisms for its efficacy remain unknown. ACTH promotes the release …

Objective: To evaluate the relationship of sleep/wake and day/night pattern to various
seizure subtypes and epilepsy localizations. Methods: Charts of 380 consecutive pediatric …

The combination of axial spasms in clusters, hypsarrhythmia, and psychomotor delay
beginning in the first year of life defines West syndrome. Variants of this classical triad …

The molecular mechanisms leading to infantile epileptic spasm syndrome (IESS) remain
obscure. The only common factor seems to be that the spasms are restricted to a limited …

West syndrome (WS) is associated with diverse etiological factors. This fact has suggested
that there must be a 'final common pathway'for these etiologies, which operates on the …

Early onset and infantile epileptic encephalopathies (EIEEs) are usually associated with
medically intractable or difficult to treat epileptic seizures and prominent cognitive …