The inescapable drive to sleep: Overlapping mechanisms of sleep and sedation
Common human experience is that a long period without sleep is unsustainable, and it is
also detrimental to health and behavior. The powerful and primal urge to sleep after sleep …
also detrimental to health and behavior. The powerful and primal urge to sleep after sleep …
[HTML][HTML] Neural substrates for the regulation of sleep and general anesthesia
Q Yang, F Zhou, A Li, H Dong - Current Neuropharmacology, 2022 - ncbi.nlm.nih.gov
General anesthesia has been successfully used in clinics for over 170 years, but its
mechanisms of effect remain unclear. Behaviorally, general anesthesia is similar to sleep as …
mechanisms of effect remain unclear. Behaviorally, general anesthesia is similar to sleep as …
Parp1 promotes sleep, which enhances DNA repair in neurons
The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …
Astroglial calcium signaling encodes sleep need in Drosophila
Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …
Cellular composition of the preoptic area regulating sleep, parental, and sexual behavior
Y Tsuneoka, H Funato - Frontiers in neuroscience, 2021 - frontiersin.org
The preoptic area (POA) has long been recognized as a sleep center, first proposed by von
Economo. The POA, especially the medial POA (MPOA), is also involved in the regulation of …
Economo. The POA, especially the medial POA (MPOA), is also involved in the regulation of …
Kinase signalling in excitatory neurons regulates sleep quantity and depth
SJ Kim, N Hotta-Hirashima, F Asano, T Kitazono… - Nature, 2022 - nature.com
Progress has been made in the elucidation of sleep and wakefulness regulation at the
neurocircuit level,. However, the intracellular signalling pathways that regulate sleep and the …
neurocircuit level,. However, the intracellular signalling pathways that regulate sleep and the …
[HTML][HTML] Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models
JE Owen, SC Veasey - Neurobiology of disease, 2020 - Elsevier
Chronic short sleep or extended wake periods are commonly observed in most
industrialized countries. Previously neurobehavioral impairment following sleep loss was …
industrialized countries. Previously neurobehavioral impairment following sleep loss was …
Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …
a transdiagnostic process that can account for behavioral deficits and influence underlying …
NMDA receptors in the lateral preoptic hypothalamus are essential for sustaining NREM and REM sleep
The lateral preoptic (LPO) hypothalamus is a center for NREM and REM sleep induction and
NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium …
NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium …
Structural insights into galanin receptor signaling
W Jiang, S Zheng - Proceedings of the National Academy of …, 2022 - National Acad Sciences
Galanin is a biologically active neuropeptide, and functions through three distinct G protein–
coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. GALR signaling plays …
coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. GALR signaling plays …