Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the
tumor by interfering with specific molecular targets and are currently the focus of anticancer …

Abstract AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of
activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse …

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that
restore the normal apoptotic pathways have the potential for effectively treating cancers that …

The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …

The abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been
validated by epidemiological and experimental studies as an essential step toward the …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

In mammalian cells, glycogen synthase kinase-3 (GSK-3) exists as two homologs, GSK-3α
and GSK-3β, encoded by independent genes, which share similar kinase domains but differ …

The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

Genistein is a small, biologically active flavonoid that is found in high amounts in soy. This
important compound possesses a wide variety of biological activities, but it is best known for …

We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay
for Akt kinase activity and screened approx. 270000 compounds for their ability to inhibit the …