Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
The role of TRIM family in metabolic associated fatty liver disease
J Zhang, Y Zhang, Z Ren, D Yan, G Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic
liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated …
liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated …
Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
C Ge, J Tan, X Dai, Q Kuang, S Zhong, L Lai… - Nature …, 2022 - nature.com
Nonalcoholic steatohepatitis (NASH), a common clinical disease, is becoming a leading
cause of hepatocellular carcinoma (HCC). Dual specificity phosphatase 22 (DUSP22, also …
cause of hepatocellular carcinoma (HCC). Dual specificity phosphatase 22 (DUSP22, also …
TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase
S Xu, X Wu, S Wang, M Xu, T Fang… - The Journal of …, 2024 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) encompasses a disease continuum from simple
steatosis to nonalcoholic steatohepatitis (NASH). However, there are currently no approved …
steatosis to nonalcoholic steatohepatitis (NASH). However, there are currently no approved …
Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2
Underestimation of the complexity of pathogenesis in nonalcoholic steatohepatitis (NASH)
significantly encumbers development of new drugs and targeted therapy strategies. Inactive …
significantly encumbers development of new drugs and targeted therapy strategies. Inactive …
Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1
H You, X Wen, X Wang, C Zhu, H Chen, L Bu… - Free Radical Biology …, 2023 - Elsevier
Background and aims The functions of liver fatty acid binding protein 1 (FABP1) in the
regulation of nonalcoholic fatty liver disease (NAFLD) have been previously established …
regulation of nonalcoholic fatty liver disease (NAFLD) have been previously established …
Tripartite motif containing 26 prevents steatohepatitis progression by suppressing C/EBPδ signalling activation
Currently potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH)
and NASH-related pathopoiesis have failed to achieve expected therapeutic efficacy due to …
and NASH-related pathopoiesis have failed to achieve expected therapeutic efficacy due to …
[HTML][HTML] Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators
KC Nikolaou, S Godbersen, M Manoharan, S Wieland… - JCI insight, 2023 - ncbi.nlm.nih.gov
Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current
therapeutic options are limited due to an incomplete mechanistic understanding of how …
therapeutic options are limited due to an incomplete mechanistic understanding of how …
[HTML][HTML] F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit
Z Liu, NY Chen, Z Zhang, S Zhou… - World Journal of …, 2023 - ncbi.nlm.nih.gov
F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl
CoA dehydrogenase alpha subunit - PMC Back to Top Skip to main content NIH NLM Logo …
CoA dehydrogenase alpha subunit - PMC Back to Top Skip to main content NIH NLM Logo …
LIM domain only 7 negatively controls nonalcoholic steatohepatitis in the setting of hyperlipidemia
T Wu, X Chen, K Xu, C Dai, X Li, J Li, M Gao, Y Liu… - Hepatology, 2024 - journals.lww.com
LIM domain only 7 negatively controls nonalcoholic steatohep... : Hepatology LIM domain
only 7 negatively controls nonalcoholic steatohepatitis in the setting of hyperlipidemia …
only 7 negatively controls nonalcoholic steatohepatitis in the setting of hyperlipidemia …