METHODS Plasma samples (times 0, 24, and 72 hours after arrival to trauma center) from
injured patients enrolled in two randomized prehospital trials were subjected to multiplexed …

Atrial fibrillation (AF) is the most common type of sustained arrhythmia in diabetes mellitus
(DM). Its morbidity and mortality rates are high, and its prevalence will increase as the …

Background Lung cancer is a malignant tumour, and early diagnosis has been shown to
improve the survival rate of lung cancer patients. In this study, we assessed the use of …

Untargeted metabolomics is the study of all detectable small molecules, and in geroscience,
metabolomics has shown great potential to describe the biological age—a complex trait …

Objective Since the COVID-19 pandemic began in early 2020, SARS-CoV2 has claimed
more than six million lives world-wide, with over 510 million cases to date. To reduce …

Background Metabolite profiles provide snapshots of the overall effect of numerous
exposures accumulated over life courses, which may lead to health outcomes in the future …

Background: No studies have examined whether the cord blood metabolome—a reflection
of in utero metabolism—influences blood pressure (BP) in children. Objectives: To examine …

Most studies on single ventricle (SV) circulation take a physiological or anatomical
approach. Although there is a tight coupling between cardiac contractility and metabolism …

Background Long-chain acyl-carnitines (ACs) are potential arrhythmogenic metabolites.
Their role in atrial fibrillation (AF) remains incompletely understood. Using a systems …

Introduction and objectives Fatty acid metabolic dysregulation in mitochondria is a common
mechanism involved in the development of heart failure (HF) and atrial fibrillation (AF). We …