[HTML][HTML] New approaches to dendritic cell-based therapeutic vaccines against HIV-1 infection

M Espinar-Buitrago, MA Muñoz-Fernández - Frontiers in immunology, 2022 - frontiersin.org
Due to the success of combined antiretroviral therapy (cART) in recent years, the
pathological outcome of Human Immunodeficiency Virus type 1 (HIV-1) infection has …

Antiretroviral treatment interruption among people living with HIV during COVID‐19 outbreak in China: a nationwide cross‐sectional study

Y Sun, H Li, G Luo, X Meng, W Guo… - Journal of the …, 2020 - Wiley Online Library
Introduction Social disruption associated with coronavirus disease 2019 (COVID‐19)
threatens to impede access to regular healthcare, including for people living with HIV …

[HTML][HTML] Analytical treatment interruption in HIV trials: statistical and study design considerations

L Zheng, C Tierney, RJ Bosch - Current HIV/AIDS Reports, 2021 - Springer
Abstract Purpose of Review Analytical treatment interruption (ATI) remains an essential
component in clinical studies investigating novel agents or combination treatment strategies …

Definition of Virological Endpoints Improving the Design of Human Immunodeficiency Virus (HIV) Cure Strategies Using Analytical Antiretroviral Treatment Interruption

M Alexandre, M Prague, E Lhomme… - Clinical Infectious …, 2024 - academic.oup.com
Background Analytical treatment interruption (ATI) is the gold standard in HIV research for
assessing the capability of new therapeutic strategies to control viremia without antiretroviral …

[HTML][HTML] Perceptions of HIV cure and willingness to participate in HIV cure-related trials among people enrolled in the Netherlands cohort study on acute HIV infection

P van Paassen, M Dijkstra, HL Peay, C Rokx… - Journal of virus …, 2022 - Elsevier
Background People who initiate antiretroviral therapy (ART) during acute HIV infection are
potential candidates for HIV cure-related clinical trials, as early ART reduces the size of the …

HIV-1 therapeutic vaccines in clinical development to intensify or replace antiretroviral therapy: the promising results of the Tat vaccine

A Cafaro, B Ensoli - Expert Review of Vaccines, 2022 - Taylor & Francis
Introduction Upon the introduction of the combination antiretroviral therapy (cART), HIV
infection has become a chronic disease. However, cART is unable to eradicate the virus and …

The Essential Need for Trust When Transmission Risk Cannot Be Eliminated in HIV‐Remission Trials

S Rennie, G Henderson, N Phanuphak… - Ethics & Human …, 2023 - Wiley Online Library
Analytic treatment interruption (ATI) is scientifically necessary in HIV‐remission (“cure”)
studies to test the effects of new interventions. However, stopping antiretroviral treatment …

[HTML][HTML] Persistent HIV-1 transcription in CD4+ T cells from ART-suppressed individuals can originate from biologically competent proviruses

M Vignoles, V Andrade, M Noguera, C Brander… - Journal of Virus …, 2021 - Elsevier
HIV-1 is able to persist in the face of potent antiretroviral therapy (ART). A number of
strategies are being explored to allow ART-free viral remission or viral eradication. In order …

Definition of viroIogical endpoints improving the design of HIV cure strategies using analytical antiretroviral treatment interruption

M Alexandre, M Prague, E Lhomme, JD Lelievre… - medRxiv, 2024 - medrxiv.org
Background. Analytical treatment interruption (ATI) is the gold standard in HIV research to
validate the ability of novel therapeutic strategies to long-term control viremia without …

[HTML][HTML] Immune-Related Gene Profile in HIV-Infected Patients with Discordant Immune Response

Y Hamidi, E Aliasgari, P Basimi… - Iranian biomedical …, 2022 - ncbi.nlm.nih.gov
Background: In spite of many reports on persistent low CD4 T cell counts and change in
immune-related gene expression level in patients with HIV infection, there is still uncertainty …