Ankylosing spondylitis (AS) is an autoimmune-related inflammatory arthritis. The association
between the DNA methylation and mRNA expression of PDCD1 gene with the susceptibility …

A dysregulated immune microenvironment at the maternal-fetal interface in early pregnancy
may lead to early pregnancy loss, fetal growth restriction, and preeclampsia. However, major …

Immune Thrombocytopenia (ITP) is an autoimmune blood disorder that involves multiple
pathways responsible for the homeostasis of the immune system. Numerous pieces of …

Background Immune thrombocytopenia (ITP) is a prevalent autoimmune disease with a
complex aetiology where DNA methylation changes are becoming triggers. Method To …

Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease
with a significant global prevalence. It is a complex condition that requires careful …

Abstract Background DNA methylation (5-mC) is being widely recognized as an alternative
in the detection of sequence variants in the diagnosis of some rare neurodevelopmental and …

Epigenetic modifications are closely related to certain disorders of the organism, including
the development of tumors. One of the main epigenetic modifications is the methylation of …

Vascular smooth muscle cells (VSMCs) are crucial components of the arterial wall,
controlling blood flow and pressure by contracting and relaxing the artery walls. VSMCs can …

While the vertebrate immune system consists of innate and adaptive branches, invertebrates
only have innate immunity. This feature makes them an ideal model system for studying the …

Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several
fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules …