[HTML][HTML] Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
[HTML][HTML] Organoids and organs-on-chips: Insights into human gut-microbe interactions
The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …
[HTML][HTML] Organoids as host models for infection biology–a review of methods
C Aguilar, M Alves da Silva, M Saraiva… - … & Molecular Medicine, 2021 - nature.com
Infectious diseases are a major threat worldwide. With the alarming rise of antimicrobial
resistance and emergence of new potential pathogens, a better understanding of the …
resistance and emergence of new potential pathogens, a better understanding of the …
Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut
S Triana, C Metz‐Zumaran, C Ramirez… - Molecular systems …, 2021 - embopress.org
Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology.
However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little …
However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little …
Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
[HTML][HTML] Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis
C Aguilar, M Pauzuolis, M Pompaiah… - Nature …, 2022 - nature.com
The human gastric epithelium forms highly organized gland structures with different
subtypes of cells. The carcinogenic bacterium Helicobacter pylori can attach to gastric cells …
subtypes of cells. The carcinogenic bacterium Helicobacter pylori can attach to gastric cells …
[HTML][HTML] Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review
JY Jang, E Im, ND Kim - International journal of molecular sciences, 2023 - mdpi.com
Scutellaria baicalensis Georgi (SBG), an herbal medicine with various biological activities,
including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is …
including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is …
Dietary resveratrol alleviated lipopolysaccharide‐induced ileitis through Nrf2 and NF‐κB signalling pathways in ducks (Anas platyrhynchos)
H Yang, Y Wang, S Jin, Q Pang… - Journal of Animal …, 2022 - Wiley Online Library
Gram‐negative bacteria contamination of feed can occur at all the stage of feed production,
storage, transportation and utilization. Lipopolysaccharide (LPS) is a major toxic metabolite …
storage, transportation and utilization. Lipopolysaccharide (LPS) is a major toxic metabolite …
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains
A key aspect of nutrient absorption is the exquisite division of labour across the length of the
small intestine, with individual nutrients taken up at different proximal: distal positions. For …
small intestine, with individual nutrients taken up at different proximal: distal positions. For …
Innate immune activation and modulatory factors of Helicobacter pylori towards phagocytic and nonphagocytic cells
L Faass, M Hauke, SC Stein, C Josenhans - Current Opinion in Immunology, 2023 - Elsevier
Highlights•H. pylori is a master influencer of the cell-autonomous immune response.•The H.
pylori Cag type 4 secretion system injects proteins and metabolites.•Bacterial heptose …
pylori Cag type 4 secretion system injects proteins and metabolites.•Bacterial heptose …