[HTML][HTML] Human disease models in drug development

A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

[HTML][HTML] Organoids and organs-on-chips: Insights into human gut-microbe interactions

J Puschhof, C Pleguezuelos-Manzano, H Clevers - Cell host & microbe, 2021 - cell.com
The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

[HTML][HTML] Organoids as host models for infection biology–a review of methods

C Aguilar, M Alves da Silva, M Saraiva… - … & Molecular Medicine, 2021 - nature.com
Infectious diseases are a major threat worldwide. With the alarming rise of antimicrobial
resistance and emergence of new potential pathogens, a better understanding of the …

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut

S Triana, C Metz‐Zumaran, C Ramirez… - Molecular systems …, 2021 - embopress.org
Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology.
However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little …

Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants

MC Chiu, C Li, X Liu, W Song, Z Wan, Y Yu, J Huang… - MBio, 2022 - Am Soc Microbiol
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …

[HTML][HTML] Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis

C Aguilar, M Pauzuolis, M Pompaiah… - Nature …, 2022 - nature.com
The human gastric epithelium forms highly organized gland structures with different
subtypes of cells. The carcinogenic bacterium Helicobacter pylori can attach to gastric cells …

[HTML][HTML] Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review

JY Jang, E Im, ND Kim - International journal of molecular sciences, 2023 - mdpi.com
Scutellaria baicalensis Georgi (SBG), an herbal medicine with various biological activities,
including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is …

Dietary resveratrol alleviated lipopolysaccharide‐induced ileitis through Nrf2 and NF‐κB signalling pathways in ducks (Anas platyrhynchos)

H Yang, Y Wang, S Jin, Q Pang… - Journal of Animal …, 2022 - Wiley Online Library
Gram‐negative bacteria contamination of feed can occur at all the stage of feed production,
storage, transportation and utilization. Lipopolysaccharide (LPS) is a major toxic metabolite …

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

RK Zwick, P Kasparek, B Palikuqi, S Viragova… - Nature Cell …, 2024 - nature.com
A key aspect of nutrient absorption is the exquisite division of labour across the length of the
small intestine, with individual nutrients taken up at different proximal: distal positions. For …

Innate immune activation and modulatory factors of Helicobacter pylori towards phagocytic and nonphagocytic cells

L Faass, M Hauke, SC Stein, C Josenhans - Current Opinion in Immunology, 2023 - Elsevier
Highlights•H. pylori is a master influencer of the cell-autonomous immune response.•The H.
pylori Cag type 4 secretion system injects proteins and metabolites.•Bacterial heptose …