Advances in experimental models of rheumatoid arthritis

S Wang, Y Zhou, J Huang, H Li, H Pang… - European journal of …, 2023 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by
persistent articular inflammation and joint damage. RA was first described over 200 years …

Pharmacological and immunomodulatory modes of action of medically important phytochemicals against arthritis: A molecular insight

Aqsa, S Ali, M Summer, S Yousaf, L Nazakat… - Molecular Biology …, 2024 - Springer
Arthritis is a common illness that affects joints and it may result in inflammation and pain.
Even though arthritis usually affects older people, it can also affect children, adults, and both …

Porous silicon-based nanomedicine for simultaneous management of joint inflammation and bone erosion in rheumatoid arthritis

M Jeong, Y Jung, J Yoon, J Kang, SH Lee, W Back… - ACS …, 2022 - ACS Publications
The lack of drugs that target both disease progression and tissue preservation makes it
difficult to effectively manage rheumatoid arthritis (RA). Here, we report a porous silicon …

Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell …

JL Mangal, S Inamdar, AP Suresh… - Biomaterials …, 2022 - pubs.rsc.org
Activated effector T cells induce pro-inflammatory responses in rheumatoid arthritis (RA)
which then lead to inflammation of the joints. In this report, we demonstrate that polymeric …

Sex differences in long-term effects of collagen-induced arthritis in middle-aged mice

BM Schuh, K Macáková, A Feješ, T Groß… - Frontiers in …, 2023 - frontiersin.org
Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with high
prevalence among middle-aged women. Collagen-induced arthritis (CIA) is the most widely …

Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats

M Ramezani, N Zainodini, R Nosratabadi… - Asian Pacific Journal …, 2022 - journals.lww.com
Objective: To explore the effects of a nano-formulation of curcumin (phytosomal curcumin)
on the clinical and pathological symptoms of collagen-induced arthritis (CIA) in rats …

High‐Sucrose Diet Accelerates Arthritis Progression in a Collagen‐Induced Rheumatoid Arthritis Model

Y Min, Y Heo, F Feng, D Kim, M Kim… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope High dietary sugar and sweeteners are suspected to cause the development of
rheumatoid arthritis (RA) symptoms through the induction of proinflammatory cytokine …

Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis

R Chaudhary, A Prasad, V Agarwal, M Rehman… - International …, 2023 - Elsevier
The global incidence of autoimmune diseases is on the rise, and many healthcare
professionals believe that chronic stress plays a prominent role in both the aggravation and …

[HTML][HTML] The mechanism of the anti-inflammatory effect of Oldenlandia diffusa on arthritis model rats: a quantitative proteomic and network pharmacologic study

H Zhu, XG Xiong, Y Lu, HC Wu, ZH Zhang… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background In China, Oldenlandia diffusa (OD) has been prescribed as a therapeutic herb
for rheumatoid arthritis (RA). We previously conducted a preliminary study of the anti …

Differentiated embryonic chondrocyte expressed gene-1 is a central signaling component in the development of collagen-induced rheumatoid arthritis

Y Wu, H Wang, Y Huo, B Yan, H Honda, W Liu… - Journal of Biological …, 2023 - ASBMB
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and affects
almost 1% of the population. Differentiated embryo-chondrocyte expressed gene-1 (DEC1) …