Molecular signaling regulating endometrium–blastocyst crosstalk

M Massimiani, V Lacconi, F La Civita, C Ticconi… - International journal of …, 2019 - mdpi.com
Implantation of the embryo into the uterine endometrium is one of the most finely-regulated
processes that leads to the establishment of a successful pregnancy. A plethora of factors …

M1/M2 macrophage polarity in normal and complicated pregnancy

MB Brown, M von Chamier, AB Allam… - Frontiers in …, 2014 - frontiersin.org
Tissue macrophages play an important role in all stages of pregnancy, including uterine
stromal remodeling (decidualization) before embryo implantation, parturition, and post …

Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans

S Murdoch, U Djuric, B Mazhar, M Seoud, R Khan… - Nature …, 2006 - nature.com
Hydatidiform mole (HM) is an abnormal human pregnancy with no embryo and cystic
degeneration of placental villi. We report five mutations in the maternal gene NALP7 in …

Animal models of implantation

KY Lee, FJ DeMayo - Reproduction, 2004 - rep.bioscientifica.com
Implantation is an intricately timed event necessary in the process of viviparous birth that
allows mammals to nourish and protect their young during early development. Human …

Decidualization of the human endometrial stromal cell: an enigmatic transformation

CL Dunn, RW Kelly, HOD Critchley - Reproductive biomedicine online, 2003 - Elsevier
Changes in human endometrium are essential to allow the establishment of pregnancy.
These changes are induced in vivo by progesterone, and include appearance within the …

Implantation and establishment of pregnancy in human and nonhuman primates

RW Su, AT Fazleabas - Regulation of Implantation and Establishment of …, 2015 - Springer
Implantation and the establishment of pregnancy are critical for the propagation of the
species, but yet remain the limiting steps in human and primate reproduction. Successful …

Altered cytokine gene expression in peripheral blood monocytes across the menstrual cycle in primary dysmenorrhea: a case-control study

H Ma, M Hong, J Duan, P Liu, X Fan, E Shang, S Su… - PloS one, 2013 - journals.plos.org
Primary dysmenorrhea is one of the most common gynecological complaints in young
women, but potential peripheral immunologic features underlying this condition remain …

Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates

Y Afshar, L Miele, AT Fazleabas - Endocrinology, 2012 - academic.oup.com
No other tissue in the body undergoes such a vast and extensive growth and remodeling in
a relatively short period of time as the primate endometrium. Endometrial integrity is …

Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation

EP Tierney, S Tulac, STJ Huang… - Physiological …, 2003 - journals.physiology.org
Decidualization of endometrial stromal cells is a prerequisite for human implantation and
occurs in vivo in response to progesterone and involves activation of the protein kinase A …

Signal transduction in trophoblast invasion

JS Fitzgerald, S Busch, T Wengenmayer… - Immunology of gametes …, 2005 - karger.com
During the first trimester of pregnancy, well-differentiated primary cells of the placenta known
as trophoblast cells grow in an invasive and destructive fashion similar to malignancies, but …