Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel
therapeutic compounds. However, interspecies differences in the mechanisms regulating …

Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …

Maintenance of normal cardiac rhythm requires coordinated activity of ion channels and
transporters that allow well-ordered propagation of electrical impulses across the …

Advanced computational techniques and mathematical modeling have become more and
more important to the study of cardiac electrophysiology. In this review, we provide a brief …

Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid
arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can …

We developed a mathematical model to simulate the dynamics of background synaptic
noise in non-neuronal cells. By employing the stochastic Ornstein–Uhlenbeck process, we …