Comprehensive review on the Bis–heterocyclic compounds and their anticancer efficacy

MHA Al-Jumaili, AA Hamad, HE Hashem… - Journal of Molecular …, 2023 - Elsevier
Heterocyclic compounds are one of the largest family of organic compounds with broad
range of applications in medicinal chemistry and agrochemicals product. Bis-heterocycle …

Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile

SK Ramadan, AK El-Ziaty… - Synthetic Communications, 2021 - Taylor & Francis
A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …

Cross-linked chitosan/multi-walled carbon nanotubes composite as ecofriendly biocatalyst for synthesis of some novel benzil bis-thiazoles

LA Alshabanah, SM Gomha, LA Al-Mutabagani… - Polymers, 2021 - mdpi.com
Aminohydrazide cross-linked chitosan (CLCS) and its MWCNTs (CLCS/MWCNTs) were
formulated and utilized as a potent ecofriendly basic heterogeneous biocatalyst under …

Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease

SM Gomha, SM Riyadh, MH Abdellattif… - Current Issues in …, 2022 - mdpi.com
A novel series of bis-[1, 3, 4] thiadiazolimines, and bis-thiazolimines, with alkyl linker, were
synthesized through general routes from cyclization of 1, 1′-(hexane-1, 6-diyl) bis (3 …

3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and reactions with binucleophiles targeting heterocycles

EAE El-Helw, AK El-Ziaty - Egyptian Journal of Chemistry, 2022 - journals.ekb.eg
In this review, we reported the synthetic method used to construct thirteen derivatives of 3-
aryl/heteryl-2-cyanoacryloyl chloride followed by a focused survey on their spectral data and …

Synthesis of 1, 3, 4-Thiadiazole Derivatives Using Hydrazonoyl Bromide: Molecular Docking and Computational Studies

YH Zaki, AO Abdelhamid, AR Sayed… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Alkyl phenylcarbamodithioates were reacted with hydrazonoyl bromide 1a, b in ethanol
containing a catalytic amount of triethylamine solution to afford and 1, 3, 4-thiadiazole …

Molecular Docking Studies and Application of 6-(1-Arylmethanamino)-2-Phenyl-4H-Chromen-4-Ones as Potent Antibacterial Agents

NM Thorat, VS Khodade, AP Ingale… - Polycyclic Aromatic …, 2023 - Taylor & Francis
The present article depicts the synthesis of the series of 6-(1-arylmethanamino)-2-phenyl-4H-
chromen-4-ones and their antibacterial activity against the S. aureus. 6-(1-arylmethanamino) …

Synthesis and Anti-Tubercular (Tb) Evaluation of Bis [4-Ethylidineamino [1, 2, 4] Triazole-3-Thiol] Tethered by 1, 4-Dihydropyridine

S Abu-Melha, MM Edrees, NA Kheder, AM Saad… - Russian Journal of …, 2022 - Springer
Abstract A new series of 5, 5'-(2, 6-dimethyl-4-phenyl-1, 4-dihydropyridine-3, 5-diyl) bis [4-
(ethylideneamino)-4 H-[1, 2, 4]-triazole-3-thiol) was synthesized via keto-imine …

[HTML][HTML] Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates

MA Said, SM Riyadh, NS Al-Kaff, AA Nayl… - Arabian Journal of …, 2022 - Elsevier
A novel series of bis-(Abdelhamid et al., 2017, Banerjee et al., 2018, Bharanidharan et al.,
2022) thiadiazoles was synthesized from the reaction of precursor dimethyl 2, 2′-(1, 2 …

Design, synthesis, biological evolution and in silico studies of a novel 1, 2, 3, 4‐tetrazole fused with 1, 3, 4‐thiadiazole‐2‐amine derivatives

M Rajeswari, B Nagaraju, S Yasmintaj… - Journal of …, 2024 - Wiley Online Library
A new series of tetrazole fused with 1, 3, 4‐thiadiazole‐2‐amine (4a–j) moiety have been
synthesized. A thorough characterization of each compound was carried out using mass …